About: A118G polymorphism of OPRM1 gene is associated with schizophrenia

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Schizophrenia is ranked among multifactor diseases in whose pathogenesis, besides environmental factors, an interplay of functional polymorphisms of a larger number of candidate genes is involved. Neurodevelopmental abnormities are among the most accepted hypotheses in the etiology of schizophrenia. Recently, the role of oligodendrocytes in the development of the cortex has been cited repeatedly. During their various phases of differentiation oligodendrocytes present on their surfaces diverse receptors, among others the mu-opioid receptor (OPRM1). The study was focused on the relationship between the functional A118G polymorphism of the OPRM1 gene (rs1799971) and schizophrenia in groups of 130 male patients and 452 male controls. An association study revealed yet unpublished statistically significant difference of allelic and genotypic frequencies between the control and patient groups. Schizophrenia is ranked among multifactor diseases in whose pathogenesis, besides environmental factors, an interplay of functional polymorphisms of a larger number of candidate genes is involved. Neurodevelopmental abnormities are among the most accepted hypotheses in the etiology of schizophrenia. Recently, the role of oligodendrocytes in the development of the cortex has been cited repeatedly. During their various phases of differentiation oligodendrocytes present on their surfaces diverse receptors, among others the mu-opioid receptor (OPRM1). The study was focused on the relationship between the functional A118G polymorphism of the OPRM1 gene (rs1799971) and schizophrenia in groups of 130 male patients and 452 male controls. An association study revealed yet unpublished statistically significant difference of allelic and genotypic frequencies between the control and patient groups. (en)
Title	A118G polymorphism of OPRM1 gene is associated with schizophrenia A118G polymorphism of OPRM1 gene is associated with schizophrenia (en)
skos:prefLabel	A118G polymorphism of OPRM1 gene is associated with schizophrenia A118G polymorphism of OPRM1 gene is associated with schizophrenia (en)
skos:notation	RIV/65269705:_____/10:#0001054!RIV11-MZ0-65269705
http://linked.open...avai/riv/aktivita	P S Z
http://linked.open...avai/riv/aktivity	P(NR9298), S, Z(MSM0021622413)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Přikryl, Radovan
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fakultní nemocnice Brno / (nerozlišená součást)
http://linked.open...dnocenehoVysledku	248326
http://linked.open...ai/riv/idVysledku	RIV/65269705:_____/10:#0001054
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	schizophrenia (en)
http://linked.open.../riv/klicoveSlovo	schizophrenia
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[1B339AD1DFF9]
http://linked.open...i/riv/nazevZdroje	Journal of Molecular Neuroscience
http://linked.open...in/vavai/riv/obor	FL
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Risk factors in persistent form of hyperkinetic disorder(ADHD) .Longitudinal, clinic and molecular-genetic study.
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	41
http://linked.open...iv/tvurceVysledku	Přikryl, Radovan Šerý, Omar
http://linked.open...ain/vavai/riv/wos	000275905400028
http://linked.open...n/vavai/riv/zamer	Proteiny v metabolismu a při interakci organismů s prostředím
issn	0895-8696
number of pages	4 (xsd:int)
is http://linked.open...avai/riv/vysledek of	A118G polymorphism of OPRM1 gene is associated with schizophrenia A118G polymorphism of OPRM1 gene is associated with schizophrenia A118G polymorphism of OPRM1 gene is associated with schizophrenia

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