About: Matrix metalloproteinases

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Matrix metalloproteinases (MMPs), also known as matrixins, belong to a group of zinc-dependent proteins, which are thought to play a central role in the breakdown of extracellular matrix. Collagen, elastin, gelatin and casein are major components cleaved by MMPs. The breakdown of these components is essential for many physiological processes such as embryonic development, morphogenesis, reproduction, and tissue resorption and remodelling. MMPs also participate in pathological processes such as arthritis, cancer, cardiovascular and neurological diseases. This review summarizes current knowledge regarding these proteins, their participation in physiological and pathophysiological roles, their involvement in activation and inhibition, and their interactions with other metal-binding proteins including metallothioneins. Matrix metalloproteinases (MMPs), also known as matrixins, belong to a group of zinc-dependent proteins, which are thought to play a central role in the breakdown of extracellular matrix. Collagen, elastin, gelatin and casein are major components cleaved by MMPs. The breakdown of these components is essential for many physiological processes such as embryonic development, morphogenesis, reproduction, and tissue resorption and remodelling. MMPs also participate in pathological processes such as arthritis, cancer, cardiovascular and neurological diseases. This review summarizes current knowledge regarding these proteins, their participation in physiological and pathophysiological roles, their involvement in activation and inhibition, and their interactions with other metal-binding proteins including metallothioneins. (en)
Title	Matrix metalloproteinases Matrix metalloproteinases (en)
skos:prefLabel	Matrix metalloproteinases Matrix metalloproteinases (en)
skos:notation	RIV/62156489:43210/10:00166579!RIV12-GA0-43210___
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(GP301/09/P436), P(IAA401990701), P(NS10200)
http://linked.open...iv/cisloPeriodika	31
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Křížková, Soňa Húska, Dalibor Adam, Vojtěch Masařík, Michal Kizek, René Zítka, Ondřej
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Mendelova univerzita v Brně / Agronomická fakulta
http://linked.open...dnocenehoVysledku	269927
http://linked.open...ai/riv/idVysledku	RIV/62156489:43210/10:00166579
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	matrix metalloproteinases; pathophysiological roles; physiological roles (en)
http://linked.open.../riv/klicoveSlovo	matrix metalloproteinases pathophysiological roles physiological roles
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[609F95ECB4ED]
http://linked.open...i/riv/nazevZdroje	Current Medicinal Chemistry
http://linked.open...in/vavai/riv/obor	CB
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...vavai/riv/projekt	Metallothionein analysis in prostate carcinoma at DNA, RNA and protein level. Study of binding of platinum cytostatics to DNA structure; Influence of metallothionein Tumor markers, their determination and correlation with prostate carcinoma
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	17
http://linked.open...iv/tvurceVysledku	Adam, Vojtěch Húska, Dalibor Kizek, René Křížková, Soňa Masařík, Michal Průša, Richard Zítka, Ondřej Kukačka, Jiří
issn	0929-8673
number of pages	18 (xsd:int)
http://localhost/t...ganizacniJednotka	43210
is http://linked.open...avai/riv/vysledek of	Matrix metalloproteinases Matrix metalloproteinases

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