About: Genes for resistance to melanoma: Can we reveal them in Old Kladruber horses?

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About: Genes for resistance to melanoma: Can we reveal them in Old Kladruber horses? Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Melanoma is a highly prevalent disease in grey horses. The duplication in the syntaxin 17, causing coat colour (greying w ith age) is also associated w ith the formation of skin melanoma. A small proportion of horses do not present melanomas even in higher age. The aim of this study was to identify effects of further candidate genes involved in mechanisms of disease in a small, isolated and partially inbred (FX =0.10) model population of Old Kladruber grey horses. Fifty breeding mares w ere examined by visual inspection and classified as negative (n=26, age 7-23 years) or positive (n=24, age 7-18 years) for the presence of melanoma. Association analysis w ith 50 microsatellite loci and with 31 polymorphic markers in expressed genes w as performed. Standard two-sided chi-square and/or exact Fisher tests were used to assess associations between polymorphisms detected and variations in the presence of melanoma. Bonferroni corrections for multiple comparisons (81) w ere made. One microsatellite (HTG004 Melanoma is a highly prevalent disease in grey horses. The duplication in the syntaxin 17, causing coat colour (greying w ith age) is also associated w ith the formation of skin melanoma. A small proportion of horses do not present melanomas even in higher age. The aim of this study was to identify effects of further candidate genes involved in mechanisms of disease in a small, isolated and partially inbred (FX =0.10) model population of Old Kladruber grey horses. Fifty breeding mares w ere examined by visual inspection and classified as negative (n=26, age 7-23 years) or positive (n=24, age 7-18 years) for the presence of melanoma. Association analysis w ith 50 microsatellite loci and with 31 polymorphic markers in expressed genes w as performed. Standard two-sided chi-square and/or exact Fisher tests were used to assess associations between polymorphisms detected and variations in the presence of melanoma. Bonferroni corrections for multiple comparisons (81) w ere made. One microsatellite (HTG004 (en)
Title	Genes for resistance to melanoma: Can we reveal them in Old Kladruber horses? Genes for resistance to melanoma: Can we reveal them in Old Kladruber horses? (en)
skos:prefLabel	Genes for resistance to melanoma: Can we reveal them in Old Kladruber horses? Genes for resistance to melanoma: Can we reveal them in Old Kladruber horses? (en)
skos:notation	RIV/62156489:43210/10:00160935!RIV11-MZE-43210___
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(QH92277)
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Vrtková, Irena Putnová, Lenka
http://linked.open.../riv/druhVysledku	O - Ostatní výsledky nezařaditelné do žádného z výše uvedených druhů výsledku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Mendelova univerzita v Brně / Agronomická fakulta
http://linked.open...dnocenehoVysledku	260386
http://linked.open...ai/riv/idVysledku	RIV/62156489:43210/10:00160935
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	melanoma; rezistance; Kladruber horse (en)
http://linked.open.../riv/klicoveSlovo	Kladruber horse melanoma rezistance
http://linked.open...ontrolniKodProRIV	[C9258B206595]
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...vavai/riv/projekt	Genetic diversity and its conservation in selected horse populations in the Czech Republic
http://linked.open...UplatneniVysledku	2010
http://linked.open...iv/tvurceVysledku	Putnová, Lenka Vrtková, Irena Hořín, Petr Majzlík, Ivan Vránová, Marie Vyskočil, Mirko Hofmanová, Barbora Futas, Ján Vychodilová, Leona
http://localhost/t...ganizacniJednotka	43210

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