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rdf:type
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Description
| - In this work we described the synthesis of the sanguinarine dihydroxy metabolite 2 and its N-demethylated analogue 1. This synthesis is applicable for preparation of a sufficient amount of these compounds to serve as analytical standards, which can be used for determination or identification of benzo[c]phenanthridine oxidative metabolites in natural sources. Furthermore, the dihydroxy derivatives 1 and 2 can be subjected to evaluate their biological activity, which has never been described. According to our best knowledge, the compound 2 has been described in several papers only as a product isolated from natural sources. Derivative 1 has never been described. Both are presumed as oxidative metabolites in the biosynthesis of the benzo[c]phenanthridine alkaloids.
- In this work we described the synthesis of the sanguinarine dihydroxy metabolite 2 and its N-demethylated analogue 1. This synthesis is applicable for preparation of a sufficient amount of these compounds to serve as analytical standards, which can be used for determination or identification of benzo[c]phenanthridine oxidative metabolites in natural sources. Furthermore, the dihydroxy derivatives 1 and 2 can be subjected to evaluate their biological activity, which has never been described. According to our best knowledge, the compound 2 has been described in several papers only as a product isolated from natural sources. Derivative 1 has never been described. Both are presumed as oxidative metabolites in the biosynthesis of the benzo[c]phenanthridine alkaloids. (en)
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Title
| - Synthesis of oxidative dihydroxy metabolites of benzo[c]phenanthridines
- Synthesis of oxidative dihydroxy metabolites of benzo[c]phenanthridines (en)
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skos:prefLabel
| - Synthesis of oxidative dihydroxy metabolites of benzo[c]phenanthridines
- Synthesis of oxidative dihydroxy metabolites of benzo[c]phenanthridines (en)
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skos:notation
| - RIV/61989592:15310/13:33147708!RIV14-MSM-15310___
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http://linked.open...avai/predkladatel
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
| - P(ED0030/01/01), P(EE2.4.31.0130)
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/61989592:15310/13:33147708
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - Benzo[c]phenanthridines, Oxidative dihydroxy metabolites, Nitrogen heterocycles, Radical cyclizations (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - GB - Spojené království Velké Británie a Severního Irska
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Hlaváč, Jan
- Cankař, Petr
- Stýskala, Jakub
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http://linked.open...ain/vavai/riv/wos
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issn
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number of pages
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http://bibframe.org/vocab/doi
| - 10.1016/j.tet.2013.03.105
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http://localhost/t...ganizacniJednotka
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