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rdf:type
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rdfs:seeAlso
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Description
| - Three new polyamine conjugates with stigmasterol [(3 beta,22E)-stigmasta-5,22-dien-3-ol] were synthesized and subjected to basic antimicrobial and cytotoxic tests. The conjugate derived from spermine, (3 beta,22E)-stigmasta-5,22-dien-3-yl 4(12-amino-4,9-diaza-dodecylamino)-4-oxobutanoate (5c), displayed considerable antimicrobial activity on Staphylococcus aureus at low concentration (50 mu g mL(-1)). The cytotoxic activity was tested on cells of human T-Iymfoblastic leukemia (IC50 = 35.8 +/- 10.3 mu M (5c) and IC50 = 35.9 +/- 5.7 mu M (5b)) and normal human fibroblasts (IC50 = 38.0 +/- 2.8 mu M (5c) and IC50= 45.5 +/- 1.9 mu M (5b)). Conjugate Sa displayed no activity in both tests
- Three new polyamine conjugates with stigmasterol [(3 beta,22E)-stigmasta-5,22-dien-3-ol] were synthesized and subjected to basic antimicrobial and cytotoxic tests. The conjugate derived from spermine, (3 beta,22E)-stigmasta-5,22-dien-3-yl 4(12-amino-4,9-diaza-dodecylamino)-4-oxobutanoate (5c), displayed considerable antimicrobial activity on Staphylococcus aureus at low concentration (50 mu g mL(-1)). The cytotoxic activity was tested on cells of human T-Iymfoblastic leukemia (IC50 = 35.8 +/- 10.3 mu M (5c) and IC50 = 35.9 +/- 5.7 mu M (5b)) and normal human fibroblasts (IC50 = 38.0 +/- 2.8 mu M (5c) and IC50= 45.5 +/- 1.9 mu M (5b)). Conjugate Sa displayed no activity in both tests (en)
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Title
| - Polyamine conjugates of stigmasterol
- Polyamine conjugates of stigmasterol (en)
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skos:prefLabel
| - Polyamine conjugates of stigmasterol
- Polyamine conjugates of stigmasterol (en)
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skos:notation
| - RIV/61989592:15310/12:33142892!RIV13-MSM-15310___
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http://linked.open...avai/predkladatel
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
| - P(ED0007/01/01), P(GAP503/11/0616), P(IAA400550801), P(OC10001), Z(AV0Z40550506), Z(AV0Z50380511)
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/61989592:15310/12:33142892
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - Antimicrobial activity; Cytotoxic activity; Amide; Stigmasterol; Polyamine (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Cvačka, Josef
- Svobodová, Hana
- Wimmer, Zdeněk
- Šaman, David
- Drašar, Pavel
- Rárová, Lucie
- Vida, Norbert
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http://linked.open...ain/vavai/riv/wos
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http://linked.open...n/vavai/riv/zamer
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issn
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number of pages
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http://bibframe.org/vocab/doi
| - 10.1016/j.steroids.2012.07.009
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http://localhost/t...ganizacniJednotka
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is http://linked.open...avai/riv/vysledek
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