About: Synthesis and biological activity of 23-ethylidene-26-hydroxy-22-oxocholestane derivatives from spirostanic sapogenins

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About: Synthesis and biological activity of 23-ethylidene-26-hydroxy-22-oxocholestane derivatives from spirostanic sapogenins Goto Sponge NotDistinct Permalink

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Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.sciencedirect.com/science/article/pii/S0223523412001110
Description	The synthesis and biological evaluation of three new cholestane frameworks of the type: (25R)-3 beta,16 beta-Diacetoxy-23-ethylidene-26-hydroxy-22-oxocholestane, starting from spirostanic sapogenins of the 25R series, is described. The compounds were obtained by the reductive cleavage of the F ring of 22-oxo-23(1),26-epoxycholestane derivatives using 9-BBN. These modified derivatives exhibit cytotoxic activity against CEM and MCF7 cells and are able to induce apoptosis in them. Its effect on the cell cycle was determined. (C) 2012 Elsevier Masson SAS. All rights reserved. The synthesis and biological evaluation of three new cholestane frameworks of the type: (25R)-3 beta,16 beta-Diacetoxy-23-ethylidene-26-hydroxy-22-oxocholestane, starting from spirostanic sapogenins of the 25R series, is described. The compounds were obtained by the reductive cleavage of the F ring of 22-oxo-23(1),26-epoxycholestane derivatives using 9-BBN. These modified derivatives exhibit cytotoxic activity against CEM and MCF7 cells and are able to induce apoptosis in them. Its effect on the cell cycle was determined. (C) 2012 Elsevier Masson SAS. All rights reserved. (en)
Title	Synthesis and biological activity of 23-ethylidene-26-hydroxy-22-oxocholestane derivatives from spirostanic sapogenins Synthesis and biological activity of 23-ethylidene-26-hydroxy-22-oxocholestane derivatives from spirostanic sapogenins (en)
skos:prefLabel	Synthesis and biological activity of 23-ethylidene-26-hydroxy-22-oxocholestane derivatives from spirostanic sapogenins Synthesis and biological activity of 23-ethylidene-26-hydroxy-22-oxocholestane derivatives from spirostanic sapogenins (en)
skos:notation	RIV/61989592:15310/12:33142860!RIV13-MSM-15310___
http://linked.open...avai/predkladatel	Přírodovědecká fakulta
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(ED0007/01/01), P(GA301/08/1649)
http://linked.open...iv/cisloPeriodika	MAY
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Strnad, Miroslav Rárová, Lucie
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Palackého v Olomouci / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	172915
http://linked.open...ai/riv/idVysledku	RIV/61989592:15310/12:33142860
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Apoptosis; Antiproliferative activity; CEM; 9-BBN; Reductive cleavage; Spirostanic sapogenins (en)
http://linked.open.../riv/klicoveSlovo	Apoptosis 9-BBN Antiproliferative activity CEM Reductive cleavage Spirostanic sapogenins
http://linked.open...odStatuVydavatele	FR - Francouzská republika
http://linked.open...ontrolniKodProRIV	[A5D7EF47E3BE]
http://linked.open...i/riv/nazevZdroje	European Journal of Medicinal Chemistry
http://linked.open...in/vavai/riv/obor	ED
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	Centre of the Region Haná for Biotechnological and Agricultural Research Modulation of cell division of normal and cancer cells by cyclin-dependent kinase inhibitors
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	51
http://linked.open...iv/tvurceVysledku	Strnad, Miroslav Rárová, Lucie Farfan, Norberto Magana-Vergara, Nancy E Munoz Ocampo, J Paul Perez-Diaz, Jose Oscar H Santillan, Rosa
http://linked.open...ain/vavai/riv/wos	000304291900007
issn	0223-5234
number of pages	12 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.ejmech.2012.02.020
http://localhost/t...ganizacniJednotka	15310
is http://linked.open...avai/riv/vysledek of	Synthesis and biological activity of 23-ethylidene-26-hydroxy-22-oxocholestane derivatives from spirostanic sapogenins

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