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Description
  • Use of solid-phase synthesis for the derivatization of carboxylic acids with biotinylated spacers consisting of ethylenoxy units is described. An aminomethylated resin provided with an acid-labile aldehyde linker is used as the polymer support and three different systems with a reactive amino group are introduced. Acylation of each system was tested with a set of model carboxylic acids and afforded crude products of excellent purity. The preloaded resins are similar to the Biotin-PEG-NovaTagTM resin but offer several advantages including simple elongation of the spacer arm. The protocols described represent a very efficient way of modifying compounds to obtain ligands for affinity chromatography studies.
  • Use of solid-phase synthesis for the derivatization of carboxylic acids with biotinylated spacers consisting of ethylenoxy units is described. An aminomethylated resin provided with an acid-labile aldehyde linker is used as the polymer support and three different systems with a reactive amino group are introduced. Acylation of each system was tested with a set of model carboxylic acids and afforded crude products of excellent purity. The preloaded resins are similar to the Biotin-PEG-NovaTagTM resin but offer several advantages including simple elongation of the spacer arm. The protocols described represent a very efficient way of modifying compounds to obtain ligands for affinity chromatography studies. (en)
Title
  • Novel preloaded resins for solid-phase biotinylation of carboxylic acids
  • Novel preloaded resins for solid-phase biotinylation of carboxylic acids (en)
skos:prefLabel
  • Novel preloaded resins for solid-phase biotinylation of carboxylic acids
  • Novel preloaded resins for solid-phase biotinylation of carboxylic acids (en)
skos:notation
  • RIV/61989592:15310/11:33118309!RIV12-MSM-15310___
http://linked.open...avai/predkladatel
http://linked.open...avai/riv/aktivita
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  • P(ED0030/01/01), P(EE2.3.20.0009), S
http://linked.open...iv/cisloPeriodika
  • 44
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  • 216607
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  • RIV/61989592:15310/11:33118309
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  • Solid-phase synthesis, Biotine, PEG linker, Acylation, Affinity chromatography (en)
http://linked.open.../riv/klicoveSlovo
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  • GB - Spojené království Velké Británie a Severního Irska
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  • [00C887929F25]
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  • Tetrahedron Letters
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http://linked.open...v/svazekPeriodika
  • 52
http://linked.open...iv/tvurceVysledku
  • Cankařová, Naděžda
  • Hlaváč, Jan
  • Soural, Miroslav
  • Funk, Petr
http://linked.open...ain/vavai/riv/wos
  • 000296168300016
issn
  • 0040-4039
number of pages
http://bibframe.org/vocab/doi
  • 10.1016/j.tetlet.2011.08.115
http://localhost/t...ganizacniJednotka
  • 15310
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