About: The Ubiquitin-Proteasome System (UPS) and the Mechanism of Action of Bortezomib

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About: The Ubiquitin-Proteasome System (UPS) and the Mechanism of Action of Bortezomib Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Proteasome inhibition is a modern and surprisingly successful approach how to cancer treatment. Bortezomib(Velcade (R)) is a first-in-class proteasome inhibitor and has been approved for first-line treatment of multiple myeloma and second-line treatment of mantle cell lymphoma. There have been almost 200 clinical trials with bortezomib, both as a single agent and in combination with other drugs, for various cancers, as listed in the US National Cancer Institute database. However, bortezomib's mechanism of action remains elusive despite enormous progress in our knowledge of the cell biology of the ubiquitin-proteasome system (UPS) and bortezomib-induced signaling events in cancer cells. This review maps a rapidly growing and open body of research in both areas. Proteasome inhibition is a modern and surprisingly successful approach how to cancer treatment. Bortezomib(Velcade (R)) is a first-in-class proteasome inhibitor and has been approved for first-line treatment of multiple myeloma and second-line treatment of mantle cell lymphoma. There have been almost 200 clinical trials with bortezomib, both as a single agent and in combination with other drugs, for various cancers, as listed in the US National Cancer Institute database. However, bortezomib's mechanism of action remains elusive despite enormous progress in our knowledge of the cell biology of the ubiquitin-proteasome system (UPS) and bortezomib-induced signaling events in cancer cells. This review maps a rapidly growing and open body of research in both areas. (en)
Title	The Ubiquitin-Proteasome System (UPS) and the Mechanism of Action of Bortezomib The Ubiquitin-Proteasome System (UPS) and the Mechanism of Action of Bortezomib (en)
skos:prefLabel	The Ubiquitin-Proteasome System (UPS) and the Mechanism of Action of Bortezomib The Ubiquitin-Proteasome System (UPS) and the Mechanism of Action of Bortezomib (en)
skos:notation	RIV/61989592:15310/11:33118107!RIV12-GA0-15310___
http://linked.open...avai/predkladatel	Přírodovědecká fakulta
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(GAP304/10/0149), P(GP303/08/P137)
http://linked.open...iv/cisloPeriodika	15
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Cvek, Boris Dvořák, Zdeněk
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Palackého v Olomouci / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	236440
http://linked.open...ai/riv/idVysledku	RIV/61989592:15310/11:33118107
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	mechanism of action; bortezomib; Ubiquitin-proteasome system (en)
http://linked.open.../riv/klicoveSlovo	bortezomib Ubiquitin-proteasome system mechanism of action
http://linked.open...odStatuVydavatele	AE - Stát Spojené arabské emiráty
http://linked.open...ontrolniKodProRIV	[81925EB9C101]
http://linked.open...i/riv/nazevZdroje	Current Pharmaceutical Design
http://linked.open...in/vavai/riv/obor	FR
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	2 (xsd:int)
http://linked.open...vavai/riv/projekt	Influence of dithiocarbamate complexes with Pt(II) and Au(III) on NF-?B pathway in human tumor lines HepG2 and SK-HEP-1 Generation of hepatocyte-derived cellular models for preclinical testing of drugs
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	17
http://linked.open...iv/tvurceVysledku	Cvek, Boris Dvořák, Zdeněk
http://linked.open...ain/vavai/riv/wos	000295455800010
issn	1381-6128
number of pages	17 (xsd:int)
http://localhost/t...ganizacniJednotka	15310
is http://linked.open...avai/riv/vysledek of	The Ubiquitin-Proteasome System (UPS) and the Mechanism of Action of Bortezomib The Ubiquitin-Proteasome System (UPS) and the Mechanism of Action of Bortezomib

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