About: Effects of dinuclear copper(II) complexes with 6-(benzylamino)purine derivatives on AhR and PXR dependent expression of cytochromes P450 CYP1A2 and CYP3A4 genes in primary cultures of human hepatocytes

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About: Effects of dinuclear copper(II) complexes with 6-(benzylamino)purine derivatives on AhR and PXR dependent expression of cytochromes P450 CYP1A2 and CYP3A4 genes in primary cultures of human hepatocytes Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	A series of dinuclear copper(II) complexes of the compositions [Cu2(mi-Ln)2(mi-Cl)2Cl2] (1, 2), [Cu2-(mi-Ln)4Cl2]Cl2.2H2O (3, 4) and [Cu2(mi-Ln)4(ClO4)2](ClO4)2.xSolv (5, 6; xSolv = 4MeOH for 5 and 2EtOH for 6), involving 6-(benzylamino)purine derivatives (Ln), have been evaluated with the aim to determine their possible drug interactions and their capability to induce the expression of major drug-metabolizing cytochromes P450. A series of dinuclear copper(II) complexes of the compositions [Cu2(mi-Ln)2(mi-Cl)2Cl2] (1, 2), [Cu2-(mi-Ln)4Cl2]Cl2.2H2O (3, 4) and [Cu2(mi-Ln)4(ClO4)2](ClO4)2.xSolv (5, 6; xSolv = 4MeOH for 5 and 2EtOH for 6), involving 6-(benzylamino)purine derivatives (Ln), have been evaluated with the aim to determine their possible drug interactions and their capability to induce the expression of major drug-metabolizing cytochromes P450. (en)
Title	Effects of dinuclear copper(II) complexes with 6-(benzylamino)purine derivatives on AhR and PXR dependent expression of cytochromes P450 CYP1A2 and CYP3A4 genes in primary cultures of human hepatocytes Effects of dinuclear copper(II) complexes with 6-(benzylamino)purine derivatives on AhR and PXR dependent expression of cytochromes P450 CYP1A2 and CYP3A4 genes in primary cultures of human hepatocytes (en)
skos:prefLabel	Effects of dinuclear copper(II) complexes with 6-(benzylamino)purine derivatives on AhR and PXR dependent expression of cytochromes P450 CYP1A2 and CYP3A4 genes in primary cultures of human hepatocytes Effects of dinuclear copper(II) complexes with 6-(benzylamino)purine derivatives on AhR and PXR dependent expression of cytochromes P450 CYP1A2 and CYP3A4 genes in primary cultures of human hepatocytes (en)
skos:notation	RIV/61989592:15310/10:10212153!RIV11-GA0-15310___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA303/07/0128), P(GP305/08/P089), Z(MSM6198959218)
http://linked.open...iv/cisloPeriodika	6
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Klanicová, Alena Trávníček, Zdeněk Vrzal, Radim Dvořák, Zdeněk Štarha, Pavel
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Palackého v Olomouci / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	256301
http://linked.open...ai/riv/idVysledku	RIV/61989592:15310/10:10212153
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Human hepatocytes, cytochrome P450, dinuclear copper(II) complexes, gene induction (en)
http://linked.open.../riv/klicoveSlovo	Human hepatocytes dinuclear copper(II) complexes gene induction cytochrome P450
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[CA0D97C98B34]
http://linked.open...i/riv/nazevZdroje	Toxicology in Vitro
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Study on tissue-specific aspects of transcriptional regulation of selected P-450 enzymes and drug transporters. The role of MAP kinases in cellular signalling of aryl hydrocarbon receptor (AhR) and glucocorticoid receptor (GR)
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	25
http://linked.open...iv/tvurceVysledku	Dvořák, Zdeněk KLANICOVÁ, Alena TRÁVNÍČEK, Zdeněk VRZAL, Radim ŠTARHA, Pavel
http://linked.open...ain/vavai/riv/wos	000275991700011
http://linked.open...n/vavai/riv/zamer	Komplexní sloučeniny a oxidy přechodných kovů s využitím v bioaplikacích a nanotechnologiích
issn	0887-2333
number of pages	5 (xsd:int)
http://localhost/t...ganizacniJednotka	15310
is http://linked.open...avai/riv/vysledek of	Effects of dinuclear copper(II) complexes with 6-(benzylamino)purine derivatives on AhR and PXR dependent expression of cytochromes P450 CYP1A2 and CYP3A4 genes in primary cultures of human hepatocytes Effects of dinuclear copper(II) complexes with 6-(benzylamino)purine derivatives on AhR and PXR dependent expression of cytochromes P450 CYP1A2 and CYP3A4 genes in primary cultures of human hepatocytes Effects of dinuclear copper(II) complexes with 6-(benzylamino)purine derivatives on AhR and PXR dependent expression of cytochromes P450 CYP1A2 and CYP3A4 genes in primary cultures of human hepatocytes

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