About: Functional p53 in cells contributes to the anticancer effect of the cyclin-dependent kinase inhibitor roscovitine

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About: Functional p53 in cells contributes to the anticancer effect of the cyclin-dependent kinase inhibitor roscovitine Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Inhibitors of cyclin-dependent kinases (CDKs) undergoing clinical trials as anticancer agents usually target several CDKs in cells. Some of them are also able to increase cellular levels of p53 protein and to activate p53-regulated transcription. To define the role of p53 in the anticancer effect of selective CDK inhibitors, two related compounds roscovitine and olomoucine II were studied. Roscovitine differs functionally from its congener olomoucine II only in the selectivity towards transcriptional CDK9. Action of both compounds on proliferation, cell-cycle progression, and apoptosis was examined in RPMI-8226 cells expressing the temperature-sensitive mutant of p53 and in MCF-7 cells with wild-type p53. Both compounds blocked proliferation, decreased phosphorylation of RNA polymerase II, downregulated antiapoptotic protein Mcl-1 in both cell lines in a dose-dependent manner, and also activated p53 in MCF-7 cells. Inhibitors of cyclin-dependent kinases (CDKs) undergoing clinical trials as anticancer agents usually target several CDKs in cells. Some of them are also able to increase cellular levels of p53 protein and to activate p53-regulated transcription. To define the role of p53 in the anticancer effect of selective CDK inhibitors, two related compounds roscovitine and olomoucine II were studied. Roscovitine differs functionally from its congener olomoucine II only in the selectivity towards transcriptional CDK9. Action of both compounds on proliferation, cell-cycle progression, and apoptosis was examined in RPMI-8226 cells expressing the temperature-sensitive mutant of p53 and in MCF-7 cells with wild-type p53. Both compounds blocked proliferation, decreased phosphorylation of RNA polymerase II, downregulated antiapoptotic protein Mcl-1 in both cell lines in a dose-dependent manner, and also activated p53 in MCF-7 cells. (en)
Title	Functional p53 in cells contributes to the anticancer effect of the cyclin-dependent kinase inhibitor roscovitine Functional p53 in cells contributes to the anticancer effect of the cyclin-dependent kinase inhibitor roscovitine (en)
skos:prefLabel	Functional p53 in cells contributes to the anticancer effect of the cyclin-dependent kinase inhibitor roscovitine Functional p53 in cells contributes to the anticancer effect of the cyclin-dependent kinase inhibitor roscovitine (en)
skos:notation	RIV/61989592:15310/09:10214126!RIV11-MSM-15310___
http://linked.open...avai/riv/aktivita	P S Z
http://linked.open...avai/riv/aktivity	P(GA204/08/0511), S, Z(AV0Z50380511), Z(MSM6198959216)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Kryštof, Vladimír Strnad, Miroslav
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Palackého v Olomouci / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	315718
http://linked.open...ai/riv/idVysledku	RIV/61989592:15310/09:10214126
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	roscovitine; p53; olomoucine II; cyclin-dependent kinase; apoptosis (en)
http://linked.open.../riv/klicoveSlovo	olomoucine II p53 cyclin-dependent kinase roscovitine apoptosis
http://linked.open...odStatuVydavatele	DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV	[6A3CB5A18F2E]
http://linked.open...i/riv/nazevZdroje	Journal of Cellular Biochemistry
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	Biological activity of synthetic inhibitors of cyclin-dependent kinases
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	107
http://linked.open...iv/tvurceVysledku	Džubák, Petr Hajdúch, Marián Jorda, Radek Kryštof, Vladimír Strnad, Miroslav Paprskářová, Martina Wesierska-Gadek, Józefa
http://linked.open...ain/vavai/riv/wos	000266872300007
http://linked.open...n/vavai/riv/zamer	Mechanismy regulace růstu a vývoje rostlin na úrovni buněk, orgánů a celých organismů: fyziologické, genetické a molekulárně biologické základy Modulation of signalling and regulatory pathways in normal and cancer cells
issn	0730-2312
number of pages	10 (xsd:int)
http://localhost/t...ganizacniJednotka	15310
is http://linked.open...avai/riv/vysledek of	Functional p53 in cells contributes to the anticancer effect of the cyclin-dependent kinase inhibitor roscovitine Functional p53 in cells contributes to the anticancer effect of the cyclin-dependent kinase inhibitor roscovitine Functional p53 in cells contributes to the anticancer effect of the cyclin-dependent kinase inhibitor roscovitine

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