About: Fluorescence of sanguinarine: fundamental characteristics and analysis of interconversion between various forms

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The quaternary isoquinoline alkaloid, sanguinarine (SG) plays an important role in both traditional and modern medicine, exhibiting a wide range of biological activities. Under physiological conditions, there is an equilibrium between the quaternary cation (SG+) and a pseudobase (SGOH) forms of SG. In the gastrointestinal tract, SG is converted to dihydrosanguinarine (DHSG). All forms exhibit bright fluorescence. However, their spectra overlap, which limited the use of powerful techniques based on fluorescence spectroscopy/microscopy. Our experiments using a combination of steady-state and time-resolved techniques enabled the separation of individual components. The quaternary isoquinoline alkaloid, sanguinarine (SG) plays an important role in both traditional and modern medicine, exhibiting a wide range of biological activities. Under physiological conditions, there is an equilibrium between the quaternary cation (SG+) and a pseudobase (SGOH) forms of SG. In the gastrointestinal tract, SG is converted to dihydrosanguinarine (DHSG). All forms exhibit bright fluorescence. However, their spectra overlap, which limited the use of powerful techniques based on fluorescence spectroscopy/microscopy. Our experiments using a combination of steady-state and time-resolved techniques enabled the separation of individual components. (en)
Title	Fluorescence of sanguinarine: fundamental characteristics and analysis of interconversion between various forms Fluorescence of sanguinarine: fundamental characteristics and analysis of interconversion between various forms (en)
skos:prefLabel	Fluorescence of sanguinarine: fundamental characteristics and analysis of interconversion between various forms Fluorescence of sanguinarine: fundamental characteristics and analysis of interconversion between various forms (en)
skos:notation	RIV/61989592:15310/09:00009527!RIV11-GA0-15310___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA203/07/0564), P(GA525/07/0871), Z(MSM6198959215), Z(MSM6198959216)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Kubala, Martin Janovská, Marika
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Palackého v Olomouci / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	315289
http://linked.open...ai/riv/idVysledku	RIV/61989592:15310/09:00009527
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Hepatocytes; Acido-basic equilibrium; Decay-associated spectra; Fluorescence; Dihydrosanguinarine; Sanguinarine (en)
http://linked.open.../riv/klicoveSlovo	Acido-basic equilibrium Decay-associated spectra Fluorescence Hepatocytes Dihydrosanguinarine Sanguinarine
http://linked.open...odStatuVydavatele	DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV	[4DE6F2CDFBF0]
http://linked.open...i/riv/nazevZdroje	Analytical and Bioanalytical Chemistry
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Determination of Na+/K+-ATPase regulatory sites Detoxification of quaternary isoquinoline alkaloids in vitro and in vivo, biological activity of their metabolites
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	395
http://linked.open...iv/tvurceVysledku	Ulrichová, Jitka Kubala, Martin Šimánek, Vilím Janovská, Marika
http://linked.open...n/vavai/riv/zamer	Variabilita složek a interakcí v rostlinném patosystému a vliv faktorů prostředí na jejich projev Modulation of signalling and regulatory pathways in normal and cancer cells
issn	1618-2642
number of pages	6 (xsd:int)
http://localhost/t...ganizacniJednotka	15310
is http://linked.open...avai/riv/vysledek of	Fluorescence of sanguinarine: fundamental characteristics and analysis of interconversion between various forms Fluorescence of sanguinarine: fundamental characteristics and analysis of interconversion between various forms Fluorescence of sanguinarine: fundamental characteristics and analysis of interconversion between various forms

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