About: Directed Solid-Phase Synthesis of Trisubstituted Imidazopyridines and Imidazopyridines

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About: Directed Solid-Phase Synthesis of Trisubstituted Imidazopyridines and Imidazopyridines Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://pubs.acs.org/doi/pdf/10.1021/co500090t
Description	An efficient solid-supported method for the synthesis of imidazo[4,5-b]pyridines and imidazo[4,5-c]pyridines from 2,4-dichloro-3-nitropyridine is described. The key pyridine building block was reacted with polymer-supported amines, followed by the replacement of the second chlorine with amines, nitro group reduction and imidazole ring closure with aldehydes. Depending on the combination of polymer-supported and solution-phase reagents, the strategy allowed for the simple preparation of the target trisubstituted derivatives with variable positioning of the pyridine nitrogen atom. Additionally, after a slight modification of the method, the preparation of strictly isomeric imidazopyridines was possible. An efficient solid-supported method for the synthesis of imidazo[4,5-b]pyridines and imidazo[4,5-c]pyridines from 2,4-dichloro-3-nitropyridine is described. The key pyridine building block was reacted with polymer-supported amines, followed by the replacement of the second chlorine with amines, nitro group reduction and imidazole ring closure with aldehydes. Depending on the combination of polymer-supported and solution-phase reagents, the strategy allowed for the simple preparation of the target trisubstituted derivatives with variable positioning of the pyridine nitrogen atom. Additionally, after a slight modification of the method, the preparation of strictly isomeric imidazopyridines was possible. (en)
Title	Directed Solid-Phase Synthesis of Trisubstituted Imidazopyridines and Imidazopyridines Directed Solid-Phase Synthesis of Trisubstituted Imidazopyridines and Imidazopyridines (en)
skos:prefLabel	Directed Solid-Phase Synthesis of Trisubstituted Imidazopyridines and Imidazopyridines Directed Solid-Phase Synthesis of Trisubstituted Imidazopyridines and Imidazopyridines (en)
skos:notation	RIV/61989592:15110/14:33151960!RIV15-MSM-15110___
http://linked.open...avai/riv/aktivita	P S
http://linked.open...avai/riv/aktivity	P(EE2.3.20.0009), P(LO1304), S
http://linked.open...iv/cisloPeriodika	10
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Oždian, Tomáš Soural, Miroslav Popa, Igor
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Palackého v Olomouci / Lékařská fakulta
http://linked.open...dnocenehoVysledku	11653
http://linked.open...ai/riv/idVysledku	RIV/61989592:15110/14:33151960
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Imidazopyridines, Imidazopyridines, solid-phase synthesis, combinatorial chemistry (en)
http://linked.open.../riv/klicoveSlovo	Imidazopyridines combinatorial chemistry solid-phase synthesis
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[971610A4E85C]
http://linked.open...i/riv/nazevZdroje	ACS Combinatorial Science
http://linked.open...in/vavai/riv/obor	CC
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Podpora udržitelnosti Ústavu molekulární a translační medicíny Combinatorial chemistry in research and education
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	16
http://linked.open...iv/tvurceVysledku	Soural, Miroslav Popa, Igor Lemrová, Barbora Smyslová, Petra Oždian, Tomáš Zajdel, Pawel
http://linked.open...ain/vavai/riv/wos	000343026800007
issn	2156-8952
number of pages	8 (xsd:int)
http://bibframe.org/vocab/doi	10.1021/co500090t
http://localhost/t...ganizacniJednotka	15110

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