About: Synthesis, cytotoxic activity and fluorescence properties of a set of novel 3-hydroxyquinolin-4(1H)-ones

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About: Synthesis, cytotoxic activity and fluorescence properties of a set of novel 3-hydroxyquinolin-4(1H)-ones Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.sciencedirect.com/science/article/pii/S0040403914007588
Description	The targeted solid-phase synthesis of 3-hydroxyquinolin-4(1H)-one derivatives is described. The primary and secondary amines, 3-amino-4-(methoxycarbonyl)benzoic acid and 2-bromo-1-(4-chloro-3-nitrophenyl)ethanone were used as starting materials. The structures of the final compounds were designed in accordance with previous information obtained from structure-activity relationship studies of similar cytotoxic derivatives. Representative prepared compounds were subjected to in vitro screening of cytotoxic activity against various cancer cell lines; the results obtained are discussed. Fluorescence properties of selected compounds were also studied to compare the data with those obtained in analogous derivatives. The targeted solid-phase synthesis of 3-hydroxyquinolin-4(1H)-one derivatives is described. The primary and secondary amines, 3-amino-4-(methoxycarbonyl)benzoic acid and 2-bromo-1-(4-chloro-3-nitrophenyl)ethanone were used as starting materials. The structures of the final compounds were designed in accordance with previous information obtained from structure-activity relationship studies of similar cytotoxic derivatives. Representative prepared compounds were subjected to in vitro screening of cytotoxic activity against various cancer cell lines; the results obtained are discussed. Fluorescence properties of selected compounds were also studied to compare the data with those obtained in analogous derivatives. (en)
Title	Synthesis, cytotoxic activity and fluorescence properties of a set of novel 3-hydroxyquinolin-4(1H)-ones Synthesis, cytotoxic activity and fluorescence properties of a set of novel 3-hydroxyquinolin-4(1H)-ones (en)
skos:prefLabel	Synthesis, cytotoxic activity and fluorescence properties of a set of novel 3-hydroxyquinolin-4(1H)-ones Synthesis, cytotoxic activity and fluorescence properties of a set of novel 3-hydroxyquinolin-4(1H)-ones (en)
skos:notation	RIV/61989592:15110/14:33151900!RIV15-MSM-15110___
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(ED0030/01/01), P(EE2.3.20.0009), P(EE2.4.31.0130)
http://linked.open...iv/cisloPeriodika	26
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Soural, Miroslav Džubák, Petr Hajdúch, Marián
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Palackého v Olomouci / Lékařská fakulta
http://linked.open...dnocenehoVysledku	49018
http://linked.open...ai/riv/idVysledku	RIV/61989592:15110/14:33151900
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Solid-phase synthesis, hydroxyquinolinones, cytotoxic activity, fluorescence (en)
http://linked.open.../riv/klicoveSlovo	hydroxyquinolinones fluorescence Solid-phase synthesis cytotoxic activity
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[7AF91DE1E7BE]
http://linked.open...i/riv/nazevZdroje	Tetrahedron Letters
http://linked.open...in/vavai/riv/obor	CC
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Development and bolstering of cooperation among academic and commercial institutions with focuse on chemical and pharmaceutical research Biomedicine for regional development and human resources Combinatorial chemistry in research and education
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	55
http://linked.open...iv/tvurceVysledku	Džubák, Petr Hajdúch, Marián Motyka, Kamil Soural, Miroslav Kadrič, Jasna
http://linked.open...ain/vavai/riv/wos	000337868300004
issn	0040-4039
number of pages	4 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.tetlet.2014.04.121
http://localhost/t...ganizacniJednotka	15110

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