About: 68Ga-Triacetylfusarinine C and 68Ga-Ferrioxamine E for Aspergillus Infection Imaging: Uptake Specificity in Various Microorganisms

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: 68Ga-Triacetylfusarinine C and 68Ga-Ferrioxamine E for Aspergillus Infection Imaging: Uptake Specificity in Various Microorganisms Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Ga-68-triacetylfusarinine C (Ga-68-TAFC) and Ga-68-ferrioxamine E (Ga-68-FOXE) showed excellent targeting properties in Aspergillus fumigatus rat infection model. Here, we report on the comparison of specificity towards different microorganisms and human lung cancer cells (H1299). The in vitro uptake of Ga-68-TAFC and Ga-68-FOXE was studied in various fungal, bacterial and yeast cultures as well as in H1299 cells. The in vivo imaging was studied in fungal and bacterial rat infection and inflammation models. Ga-68-TAFC and Ga-68-FOXE showed rapid uptake in A. fumigatus cultures, significantly lower in other fungal species and almost no uptake in other microorganisms and H1299 cells, except for Ga-68-FOXE in Staphylococcus aureus. Ga-68-TAFC and Ga-68-FOXE revealed rapid uptake in the lungs of A. fumigatus-infected rats, low accumulation in sterile inflammation and no uptake in bacterial abscess. We have shown that Ga-68-FOXE and Ga-68-TAFC have high uptake in A. fumigatus both in vitro and in vivo. Ga-68-TAFC showed higher specificity, while Ga-68-FOXE showed higher sensitivity. Ga-68-triacetylfusarinine C (Ga-68-TAFC) and Ga-68-ferrioxamine E (Ga-68-FOXE) showed excellent targeting properties in Aspergillus fumigatus rat infection model. Here, we report on the comparison of specificity towards different microorganisms and human lung cancer cells (H1299). The in vitro uptake of Ga-68-TAFC and Ga-68-FOXE was studied in various fungal, bacterial and yeast cultures as well as in H1299 cells. The in vivo imaging was studied in fungal and bacterial rat infection and inflammation models. Ga-68-TAFC and Ga-68-FOXE showed rapid uptake in A. fumigatus cultures, significantly lower in other fungal species and almost no uptake in other microorganisms and H1299 cells, except for Ga-68-FOXE in Staphylococcus aureus. Ga-68-TAFC and Ga-68-FOXE revealed rapid uptake in the lungs of A. fumigatus-infected rats, low accumulation in sterile inflammation and no uptake in bacterial abscess. We have shown that Ga-68-FOXE and Ga-68-TAFC have high uptake in A. fumigatus both in vitro and in vivo. Ga-68-TAFC showed higher specificity, while Ga-68-FOXE showed higher sensitivity. (en)
Title	68Ga-Triacetylfusarinine C and 68Ga-Ferrioxamine E for Aspergillus Infection Imaging: Uptake Specificity in Various Microorganisms 68Ga-Triacetylfusarinine C and 68Ga-Ferrioxamine E for Aspergillus Infection Imaging: Uptake Specificity in Various Microorganisms (en)
skos:prefLabel	68Ga-Triacetylfusarinine C and 68Ga-Ferrioxamine E for Aspergillus Infection Imaging: Uptake Specificity in Various Microorganisms 68Ga-Triacetylfusarinine C and 68Ga-Ferrioxamine E for Aspergillus Infection Imaging: Uptake Specificity in Various Microorganisms (en)
skos:notation	RIV/61989592:15110/14:33147593!RIV15-MSM-15110___
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(ED0030/01/01)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Petřík, Miloš
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Palackého v Olomouci / Lékařská fakulta
http://linked.open...dnocenehoVysledku	58354
http://linked.open...ai/riv/idVysledku	RIV/61989592:15110/14:33147593
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Positron emission tomography; Aspergillus fumigatus; Infection imaging; Gallium-68; Siderophores (en)
http://linked.open.../riv/klicoveSlovo	Aspergillus fumigatus Gallium-68 Siderophores Positron emission tomography Infection imaging
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[F8947DFEAA52]
http://linked.open...i/riv/nazevZdroje	MOLECULAR IMAGING AND BIOLOGY
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	Biomedicine for regional development and human resources
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	16
http://linked.open...iv/tvurceVysledku	Decristoforo, Clemens Petřík, Miloš Franssen, Gerben M Haas, Hubertus Laverman, Peter Schrettl, Markus Blatzer, Michael
http://linked.open...ain/vavai/riv/wos	000329793200013
issn	1536-1632
number of pages	7 (xsd:int)
http://bibframe.org/vocab/doi	10.1007/s11307-013-0654-7
http://localhost/t...ganizacniJednotka	15110

Faceted Search & Find service v1.16.118 as of Jun 21 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 47 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software