About: The Chromatin Scaffold Protein SAFB1 Renders Chromatin Permissive for DNA Damage Signaling

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Although the general relevance of chromatin modifications for genotoxic stress signaling, cell-cycle checkpoint activation, and DNA repair is well established, how these modifications reach initial thresholds in order to trigger robust responses remains largely unexplored. Here, we identify the chromatin-associated scaffold attachment factor SAFB1 as a component of the DNA damage response and show that SAFB1 cooperates with histone acetylation to allow for efficient gamma H2AX spreading and genotoxic stress signaling. SAFB1 undergoes a highly dynamic exchange at damaged chromatin in a poly(ADP-ribose)-polymerase 1- and poly(ADP-ribose)-dependent manner and is required for unperturbed cell-cycle checkpoint activation and guarding cells against replicative stress. Altogether, our data reveal that transient recruitment of an architectural chromatin component is required in order to overcome physiological barriers by making chromatin permissive for DNA damage signaling, whereas the ensuing exclusion of SAFB1 may help prevent excessive signaling. Although the general relevance of chromatin modifications for genotoxic stress signaling, cell-cycle checkpoint activation, and DNA repair is well established, how these modifications reach initial thresholds in order to trigger robust responses remains largely unexplored. Here, we identify the chromatin-associated scaffold attachment factor SAFB1 as a component of the DNA damage response and show that SAFB1 cooperates with histone acetylation to allow for efficient gamma H2AX spreading and genotoxic stress signaling. SAFB1 undergoes a highly dynamic exchange at damaged chromatin in a poly(ADP-ribose)-polymerase 1- and poly(ADP-ribose)-dependent manner and is required for unperturbed cell-cycle checkpoint activation and guarding cells against replicative stress. Altogether, our data reveal that transient recruitment of an architectural chromatin component is required in order to overcome physiological barriers by making chromatin permissive for DNA damage signaling, whereas the ensuing exclusion of SAFB1 may help prevent excessive signaling. (en)
Title	The Chromatin Scaffold Protein SAFB1 Renders Chromatin Permissive for DNA Damage Signaling The Chromatin Scaffold Protein SAFB1 Renders Chromatin Permissive for DNA Damage Signaling (en)
skos:prefLabel	The Chromatin Scaffold Protein SAFB1 Renders Chromatin Permissive for DNA Damage Signaling The Chromatin Scaffold Protein SAFB1 Renders Chromatin Permissive for DNA Damage Signaling (en)
skos:notation	RIV/61989592:15110/13:33145141!RIV14-MSM-15110___
http://linked.open...avai/predkladatel	Lékařská fakulta
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(ED0030/01/01)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Bártek, Jiří
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Palackého v Olomouci / Lékařská fakulta
http://linked.open...dnocenehoVysledku	65391
http://linked.open...ai/riv/idVysledku	RIV/61989592:15110/13:33145141
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	FOCUS; SITES; BREAKS; STRESS; DYNAMICS; INTERACTS; INHIBITOR; RECOMBINATION; CELLS; SCREEN REVEALS (en)
http://linked.open.../riv/klicoveSlovo	CELLS STRESS INHIBITOR DYNAMICS BREAKS FOCUS RECOMBINATION SCREEN REVEALS SITES INTERACTS
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[87B7DFF09B83]
http://linked.open...i/riv/nazevZdroje	Molecular Cell
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	10 (xsd:int)
http://linked.open...vavai/riv/projekt	Biomedicine for regional development and human resources
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	52
http://linked.open...iv/tvurceVysledku	Bártek, Jiří Lukas, J. Lukas, C. Altmeyer, M. Grofte, M. Gudjonsson, T. Toledo, L. Rask, M. B. Akimov, V. Blagoev, B.
http://linked.open...ain/vavai/riv/wos	000326316300008
issn	1097-2765
number of pages	15 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.molcel.2013.08.025
http://localhost/t...ganizacniJednotka	15110

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