| Attributes | Values |
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| rdf:type
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| Description
| - NQO1 participates in cellular defense against oxidative stress and regulates apoptosis via p53- and NF kappa B-mediated pathways. We have previously found that homozygous missense variant NQO1*2 (rs1800566) predicts poor survival among breast cancer patients, particularly after anthracycline-based adjuvant chemotherapy. Here, we investigated NQO1 and NF kappa B protein expression and global gene expression profiles in breast tumors with correlation to tumor characteristics and survival after adjuvant chemotherapy. We used immunohistochemical analysis of tissue microarrays to study NQO1 and NF kappa B expression in two series of tumors: 1000 breast tumors unselected for treatment and 113 from a clinical trial comparing chemotherapy regimens after anthracycline treatment in advanced breast cancer. We used gene expression arrays to define genes co-expressed with NQO1 and NF kappa B. NQO1 and nuclear NF kappa B were expressed in 83% and 11% of breast tumors, and correlated inversely (P = 0.012). NQO1 protein expression was associated with estrogen receptor (ER) expression (P = 0.011), whereas 34.5% of NF kappa B-nuclear/activated tumors were ER negative (P = 0.001). NQO1 protein expression and NF kappa B activation showed only trends, but no statistical significance for patient survival or outcome after anthracycline treatment. Gene expression analysis highlighted 193 genes that significantly correlated with both NQO1 and NF kappa B in opposite directions, consistent with the expression patterns of the two proteins. Inverse correlation was found with genes related to oxidation/reduction, lipid biosynthesis and steroid metabolism, immune response, lymphocyte activation, Jak-STAT signaling and apoptosis. The inverse relationship between NQO1 protein expression and NF kappa B activation, ...
- NQO1 participates in cellular defense against oxidative stress and regulates apoptosis via p53- and NF kappa B-mediated pathways. We have previously found that homozygous missense variant NQO1*2 (rs1800566) predicts poor survival among breast cancer patients, particularly after anthracycline-based adjuvant chemotherapy. Here, we investigated NQO1 and NF kappa B protein expression and global gene expression profiles in breast tumors with correlation to tumor characteristics and survival after adjuvant chemotherapy. We used immunohistochemical analysis of tissue microarrays to study NQO1 and NF kappa B expression in two series of tumors: 1000 breast tumors unselected for treatment and 113 from a clinical trial comparing chemotherapy regimens after anthracycline treatment in advanced breast cancer. We used gene expression arrays to define genes co-expressed with NQO1 and NF kappa B. NQO1 and nuclear NF kappa B were expressed in 83% and 11% of breast tumors, and correlated inversely (P = 0.012). NQO1 protein expression was associated with estrogen receptor (ER) expression (P = 0.011), whereas 34.5% of NF kappa B-nuclear/activated tumors were ER negative (P = 0.001). NQO1 protein expression and NF kappa B activation showed only trends, but no statistical significance for patient survival or outcome after anthracycline treatment. Gene expression analysis highlighted 193 genes that significantly correlated with both NQO1 and NF kappa B in opposite directions, consistent with the expression patterns of the two proteins. Inverse correlation was found with genes related to oxidation/reduction, lipid biosynthesis and steroid metabolism, immune response, lymphocyte activation, Jak-STAT signaling and apoptosis. The inverse relationship between NQO1 protein expression and NF kappa B activation, ... (en)
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| Title
| - NQO1 expression correlates inversely with NF kappa B activation in human breast cancer
- NQO1 expression correlates inversely with NF kappa B activation in human breast cancer (en)
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| skos:prefLabel
| - NQO1 expression correlates inversely with NF kappa B activation in human breast cancer
- NQO1 expression correlates inversely with NF kappa B activation in human breast cancer (en)
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| skos:notation
| - RIV/61989592:15110/12:33141807!RIV13-MZ0-15110___
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| http://linked.open...avai/predkladatel
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
| - P(ED0030/01/01), P(NS10282), Z(MSM6198959216)
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
| |
| http://linked.open...iv/duvernostUdaju
| |
| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
| |
| http://linked.open...ai/riv/idVysledku
| - RIV/61989592:15110/12:33141807
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| http://linked.open...riv/jazykVysledku
| |
| http://linked.open.../riv/klicovaSlova
| - POLYMORPHISM; CELLS; PROGNOSTIC-FACTORS; PROTEIN EXPRESSION; PROTEASOMAL DEGRADATION; CONSTITUTIVE ACTIVATION; BRCA2 MUTATIONS; QUINONE OXIDOREDUCTASE-1; NAD(P)H-QUINONE OXIDOREDUCTASE-1; NAD(P)HQUINONE OXIDOREDUCTASE 1 (en)
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| http://linked.open.../riv/klicoveSlovo
| |
| http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
| - BREAST CANCER RESEARCH AND TREATMENT
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| http://linked.open...in/vavai/riv/obor
| |
| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
| |
| http://linked.open...vavai/riv/projekt
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| http://linked.open...UplatneniVysledku
| |
| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Bártek, Jiří
- Bartkova, J.
- Lukas, J.
- Aittomäki, K.
- Vrtěl, Radek
- Blomqvist, C.
- Fagerholm, R.
- Greco, D.
- Heikkilä, P.
- Jamshidi, M.
- Mattson, J.
- Nevanlinna, H.
- Tommiska, J.
- Villman, K.
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| http://linked.open...ain/vavai/riv/wos
| |
| http://linked.open...n/vavai/riv/zamer
| |
| issn
| |
| number of pages
| |
| http://bibframe.org/vocab/doi
| - 10.1007/s10549-011-1629-5
|
| http://localhost/t...ganizacniJednotka
| |
| is http://linked.open...avai/riv/vysledek
of | |
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