About: T-helper cell type-1 transcription factor T-bet is upregulated in pulmonary sarcoidosis

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About: T-helper cell type-1 transcription factor T-bet is upregulated in pulmonary sarcoidosis Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Upregulation of genes for interferon (IFN)-gama and CXC chemokine receptor (CXCR)3 expression, two crucial molecules in sarcoid inflammation and granuloma formation, is directly controlled by the T-helper (Th)1 transcription factor T-bet (T-box, expressed in T-cells). However, there is no information on T-bet expression in sarcoidosis or its relationship with %22sarcoidosis-associated%22 genes. Therefore, we investigated expression of T-bet mRNA and, in parallel, a spectrum of genes known to be involved in sarcoidosis pathogenesis. Transcripts were determined in bronchoalveolar lavage (BAL) cells from 62 sarcoidosis patients and 25 controls by quantitative RT-PCR; T-bet protein was localised by immunohistochemistry. Patient's BAL cells expressed higher mRNA T-bet levels than those of controls (mean+-sd fold change 3.64+-1.72; p=0.00006). Upregulation of genes for interferon (IFN)-gama and CXC chemokine receptor (CXCR)3 expression, two crucial molecules in sarcoid inflammation and granuloma formation, is directly controlled by the T-helper (Th)1 transcription factor T-bet (T-box, expressed in T-cells). However, there is no information on T-bet expression in sarcoidosis or its relationship with %22sarcoidosis-associated%22 genes. Therefore, we investigated expression of T-bet mRNA and, in parallel, a spectrum of genes known to be involved in sarcoidosis pathogenesis. Transcripts were determined in bronchoalveolar lavage (BAL) cells from 62 sarcoidosis patients and 25 controls by quantitative RT-PCR; T-bet protein was localised by immunohistochemistry. Patient's BAL cells expressed higher mRNA T-bet levels than those of controls (mean+-sd fold change 3.64+-1.72; p=0.00006). (en)
Title	T-helper cell type-1 transcription factor T-bet is upregulated in pulmonary sarcoidosis T-helper cell type-1 transcription factor T-bet is upregulated in pulmonary sarcoidosis (en)
skos:prefLabel	T-helper cell type-1 transcription factor T-bet is upregulated in pulmonary sarcoidosis T-helper cell type-1 transcription factor T-bet is upregulated in pulmonary sarcoidosis (en)
skos:notation	RIV/61989592:15110/11:10224175!RIV12-MZ0-15110___
http://linked.open...avai/predkladatel	Lékařská fakulta
http://linked.open...avai/riv/aktivita	P S
http://linked.open...avai/riv/aktivity	P(ED0030/01/01), P(NS10267), P(NT11117), S
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Petřek, Martin Mrázek, František Kolek, Vítězslav Tománková, Tereza FILLEROVÁ, Regina Kriegová, Eva Tichý, Tomáš HUTYROVÁ, Beáta
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Palackého v Olomouci / Lékařská fakulta
http://linked.open...dnocenehoVysledku	235077
http://linked.open...ai/riv/idVysledku	RIV/61989592:15110/11:10224175
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	CCL5; chemokines; CXCR6; CXCR3; INFG; lung inflammation (en)
http://linked.open.../riv/klicoveSlovo	CXCR3 CXCR6 INFG chemokines CCL5 lung inflammation
http://linked.open...odStatuVydavatele	DK - Dánské království
http://linked.open...ontrolniKodProRIV	[A52CA488CFD7]
http://linked.open...i/riv/nazevZdroje	European Respiratory Journal
http://linked.open...in/vavai/riv/obor	EC
http://linked.open...ichTvurcuVysledku	8 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...vavai/riv/projekt	Study of mediators of fibrotic processes in patients with diffuse lung diseases and their clinical application Biomedicine for regional development and human resources Expression profiling of immunological biomarkers in different stages of chronic obstructive pulmonary disease
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	38
http://linked.open...iv/tvurceVysledku	Petřek, Martin Tichý, Tomáš FILLEROVÁ, Regina KOLEK, Vítězslav KRIEGOVÁ, Eva MRÁZEK, František HUTYROVÁ, Beáta TOMÁNKOVÁ, Tereza du Bois, Roland M.
issn	0903-1936
number of pages	9 (xsd:int)
http://localhost/t...ganizacniJednotka	15110
is http://linked.open...avai/riv/vysledek of	T-helper cell type-1 transcription factor T-bet is upregulated in pulmonary sarcoidosis T-helper cell type-1 transcription factor T-bet is upregulated in pulmonary sarcoidosis

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