About: The Ras related GTPase Miro is not required for mitochondrial transport in Dictyostelium discoideum

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: The Ras related GTPase Miro is not required for mitochondrial transport in Dictyostelium discoideum Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	We disrupted the single Miro-encoding gene in Dictyostelium discoideum and observed a substantial growth defect that we attribute to a decreased mitochondrial mass and cellular ATP content. However, mutant cells even showed an increased rate of oxygen consumption, while glucose consumption, mitochondrial transmembrane potential and production of reactive oxygen species were unaltered. Processes characteristic of the multicellular stage of the D. discoideum life cycle were also unaltered. Although mitochondria occasionally use microtubules for transport in D. discoideum, their size and distribution were not visibly affected. We found Miro in all branches of the eukaryotic tree with the exception of a few protist lineages (mainly those lacking typical mitochondria). We propose that in D. discoideum Miro plays roles in mitochondrial homeostasis, but the ability to build a complex that regulates its association to kinesin for microtubule-dependent transport probably arose in metazoans. We disrupted the single Miro-encoding gene in Dictyostelium discoideum and observed a substantial growth defect that we attribute to a decreased mitochondrial mass and cellular ATP content. However, mutant cells even showed an increased rate of oxygen consumption, while glucose consumption, mitochondrial transmembrane potential and production of reactive oxygen species were unaltered. Processes characteristic of the multicellular stage of the D. discoideum life cycle were also unaltered. Although mitochondria occasionally use microtubules for transport in D. discoideum, their size and distribution were not visibly affected. We found Miro in all branches of the eukaryotic tree with the exception of a few protist lineages (mainly those lacking typical mitochondria). We propose that in D. discoideum Miro plays roles in mitochondrial homeostasis, but the ability to build a complex that regulates its association to kinesin for microtubule-dependent transport probably arose in metazoans. (en)
Title	The Ras related GTPase Miro is not required for mitochondrial transport in Dictyostelium discoideum The Ras related GTPase Miro is not required for mitochondrial transport in Dictyostelium discoideum (en)
skos:prefLabel	The Ras related GTPase Miro is not required for mitochondrial transport in Dictyostelium discoideum The Ras related GTPase Miro is not required for mitochondrial transport in Dictyostelium discoideum (en)
skos:notation	RIV/61988987:17310/11:A1201431!RIV12-GA0-17310___
http://linked.open...avai/predkladatel	Přírodovědecká fakulta
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(GAP305/10/0205)
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Eliáš, Marek
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ostravská univerzita v Ostravě / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	225722
http://linked.open...ai/riv/idVysledku	RIV/61988987:17310/11:A1201431
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Miro; Mitochondrial transport; Small GTPase; Dictyostelium (en)
http://linked.open.../riv/klicoveSlovo	Dictyostelium Miro Mitochondrial transport Small GTPase
http://linked.open...odStatuVydavatele	DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV	[115731642B21]
http://linked.open...i/riv/nazevZdroje	EUR J CELL BIOL
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	The Ras superfamily of GTPases and the evolution of the eukaryotic cell
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	90
http://linked.open...iv/tvurceVysledku	Eliáš, Marek Rivero, Francisco Vlahou, Georgia Wiesner, Rudolf J. von Kleist-Retzow, Jürgen-Christoph
http://linked.open...ain/vavai/riv/wos	000289387400007
issn	0171-9335
number of pages	14 (xsd:int)
http://localhost/t...ganizacniJednotka	17310
is http://linked.open...avai/riv/vysledek of	The Ras related GTPase Miro is not required for mitochondrial transport in Dictyostelium discoideum The Ras related GTPase Miro is not required for mitochondrial transport in Dictyostelium discoideum

Faceted Search & Find service v1.16.118 as of Jun 21 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 77 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software