About: Synthesis, characterization and biological activity of ring-substituted 6-benzylamino-9-tetrahydropyran-2-yl and 9-tetrahydrofuran-2-ylpurine derivatives

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About: Synthesis, characterization and biological activity of ring-substituted 6-benzylamino-9-tetrahydropyran-2-yl and 9-tetrahydrofuran-2-ylpurine derivatives Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	In an attempt to improve specific biological functions of cytokinins routinely used in plant micropropagation, thirty-three 6-benzylamino-9-tetrahydropyran-2-ylpurine (THPP) and 9-tetrahydrofuran-2-ylpurine (THFP) derivatives were prepared. The new derivatives were prepared by condensation of 6-chloropurine with 3,4-dihydro-2H-pyran or 2,3-dihydrofuran and then by the condensation with the corresponding benzylamines. The prepared compounds were characterized by elemental analyses, TLC, HPLC, melting point determinations, CI+ MS and 1H NMR spectroscopy. The cytokinin activity of all the prepared derivatives was assessed in three classical cytokinin bioassays as well as receptor assay. Subsequently, the susceptibility of several new derivatives to enzyme degradation was studied. To provide a practical perspective, , the pH stability and cytotoxicity of the prepared compounds against human diploid fibroblasts and the human cancer cell lines K-562 and MCF-7 was also assayed. In an attempt to improve specific biological functions of cytokinins routinely used in plant micropropagation, thirty-three 6-benzylamino-9-tetrahydropyran-2-ylpurine (THPP) and 9-tetrahydrofuran-2-ylpurine (THFP) derivatives were prepared. The new derivatives were prepared by condensation of 6-chloropurine with 3,4-dihydro-2H-pyran or 2,3-dihydrofuran and then by the condensation with the corresponding benzylamines. The prepared compounds were characterized by elemental analyses, TLC, HPLC, melting point determinations, CI+ MS and 1H NMR spectroscopy. The cytokinin activity of all the prepared derivatives was assessed in three classical cytokinin bioassays as well as receptor assay. Subsequently, the susceptibility of several new derivatives to enzyme degradation was studied. To provide a practical perspective, , the pH stability and cytotoxicity of the prepared compounds against human diploid fibroblasts and the human cancer cell lines K-562 and MCF-7 was also assayed. (en)
Title	Synthesis, characterization and biological activity of ring-substituted 6-benzylamino-9-tetrahydropyran-2-yl and 9-tetrahydrofuran-2-ylpurine derivatives Synthesis, characterization and biological activity of ring-substituted 6-benzylamino-9-tetrahydropyran-2-yl and 9-tetrahydrofuran-2-ylpurine derivatives (en)
skos:prefLabel	Synthesis, characterization and biological activity of ring-substituted 6-benzylamino-9-tetrahydropyran-2-yl and 9-tetrahydrofuran-2-ylpurine derivatives Synthesis, characterization and biological activity of ring-substituted 6-benzylamino-9-tetrahydropyran-2-yl and 9-tetrahydrofuran-2-ylpurine derivatives (en)
skos:notation	RIV/61389030:_____/09:00328721!RIV10-MSM-61389030
http://linked.open...avai/riv/aktivita	P S Z
http://linked.open...avai/riv/aktivity	P(1M06030), P(GA522/08/0920), P(GA522/09/1576), S, Z(AV0Z50380511), Z(MSM6198959216)
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Spíchal, Lukáš Voller, Jiří Zatloukal, Marek Kryštof, Vladimír Doležal, Karel Greplová, Jarmila Strnad, Miroslav Popa, Igor Szüčová, Lucie
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav experimentální botaniky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	345085
http://linked.open...ai/riv/idVysledku	RIV/61389030:_____/09:00328721
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Cytokinins; Antisenescence; Receptor (en)
http://linked.open.../riv/klicoveSlovo	Cytokinins Receptor Antisenescence
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[F957526A5795]
http://linked.open...i/riv/nazevZdroje	Bioorganic & Medicinal Chemistry
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	9 (xsd:int)
http://linked.open...cetTvurcuVysledku	12 (xsd:int)
http://linked.open...vavai/riv/projekt	Effect of synthetic cytokinin analogues on plant hormone perception, metabolism and phenotypic alterations Functional genomics and proteomics for crop improvement Development of biospecific ligands for affinity chromatography of cytokinin related proteins.
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	17
http://linked.open...iv/tvurceVysledku	Doležal, Karel Kryštof, Vladimír Strnad, Miroslav Spíchal, Lukáš Voller, Jiří Zatloukal, Marek Popa, Igor Galuszka, P. Szüčová, Lucie Massino, F. J. Greplová, Jarmila Jorgensen, J. E.
http://linked.open...ain/vavai/riv/wos	000264067900020
http://linked.open...n/vavai/riv/zamer	Mechanismy regulace růstu a vývoje rostlin na úrovni buněk, orgánů a celých organismů: fyziologické, genetické a molekulárně biologické základy Modulation of signalling and regulatory pathways in normal and cancer cells
issn	0968-0896
number of pages	10 (xsd:int)
is http://linked.open...avai/riv/vysledek of	Synthesis, characterization and biological activity of ring-substituted 6-benzylamino-9-tetrahydropyran-2-yl and 9-tetrahydrofuran-2-ylpurine derivatives Synthesis, characterization and biological activity of ring-substituted 6-benzylamino-9-tetrahydropyran-2-yl and 9-tetrahydrofuran-2-ylpurine derivatives Synthesis, characterization and biological activity of ring-substituted 6-benzylamino-9-tetrahydropyran-2-yl and 9-tetrahydrofuran-2-ylpurine derivatives Synthesis, characterization and biological activity of ring-substituted 6-benzylamino-9-tetrahydropyran-2-yl and 9-tetrahydrofuran-2-ylpurine derivatives

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