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  • To find out if the cancer protective effects of Brussels sprouts seen in epidemiological studies are due to protection against DNA-damage, an intervention trial was conducted in which the impact of vegetable consumption on DNA-stability was monitored in lymphocytes with the comet assay. After consumption of the sprouts (300 g/p/d, n = 8), a reduction of DNA-migration (97%) induced by the heterocyclic aromatic amine 2-amino-1-methyl-6-phenyl-imidazo-[4,5-b]pyridine (PhIP) was observed whereas no effect was seen with 3-amino-1-methyl-5H-pyrido[4,3-b]-indole (Trp-P-2). This effect protection may be due to inhibition of sulfotransferase 1A1, which plays a key role in the activation of PhIP. In addition, a decrease of the endogenous formation of oxidized bases was observed and DNA-damage caused by hydrogen peroxide was significantly (39%) lower after the intervention. These effects could not be explained by induction of antioxidant enzymes glutathione peroxidase and superoxide dismutase, but in vitro ex...
  • To find out if the cancer protective effects of Brussels sprouts seen in epidemiological studies are due to protection against DNA-damage, an intervention trial was conducted in which the impact of vegetable consumption on DNA-stability was monitored in lymphocytes with the comet assay. After consumption of the sprouts (300 g/p/d, n = 8), a reduction of DNA-migration (97%) induced by the heterocyclic aromatic amine 2-amino-1-methyl-6-phenyl-imidazo-[4,5-b]pyridine (PhIP) was observed whereas no effect was seen with 3-amino-1-methyl-5H-pyrido[4,3-b]-indole (Trp-P-2). This effect protection may be due to inhibition of sulfotransferase 1A1, which plays a key role in the activation of PhIP. In addition, a decrease of the endogenous formation of oxidized bases was observed and DNA-damage caused by hydrogen peroxide was significantly (39%) lower after the intervention. These effects could not be explained by induction of antioxidant enzymes glutathione peroxidase and superoxide dismutase, but in vitro ex... (en)
  • Pro ověření protektivního efektu kadeřavé kapusty známého z epidemiologických studií spočívajícího v ochraně proti poškození DNA byl proveden pokus studující vliv konzumace zeleniny na stabilitu DNA monitorovanou metodou komet v periferních lymfocytech. Po konzumaci růžiček kapusty (300 g/p/d, n = 8), byl pozorován pokles migrace DNA indukovaný heterocyclickým aromatickým amine 2-amino-1-methyl-6-phenyl-imidazo-[4,5-b]pyridine (PhIP) o 97% zatímco žádný efekt nebyl pozorován po působení 3-amino-1-methyl-5H-pyrido[4,3-b]-indole (Trp-P-2). Tento protektivní efekt může být důsledkem inhibice sulfotransferasy 1A1 hrající klíčovou úlohu při aktivaci PhIP. Navíc byl pozorován výrazný pokles (37%) tvorby endogenních oxidovaných bazí a poškození DNA vyvolaných peroxidem vodíku po konzumaci růžiček kapusty. Tento účinek nelze vysvětlit indukcí antioxidačního enzymů glutathione peroxidasy a superoxide dismutasy, ale v in vitro experimentech se ukazuje, že růžičky kapusty obsahují látky, které fungují jako př... (cs)
Title
  • Consumption of Brussels sprouts protects peripheral human lymphocytes against 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhlP) and oxidative DNA-damage: results of a controlled human intervention trial
  • Konzumace kadeřavé kapusty chrání lidské periferní lymfocyty proti 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) a oxidativnímu poškození DNA: výsledek pokusu s podáním lidem (cs)
  • Consumption of Brussels sprouts protects peripheral human lymphocytes against 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhlP) and oxidative DNA-damage: results of a controlled human intervention trial (en)
skos:prefLabel
  • Consumption of Brussels sprouts protects peripheral human lymphocytes against 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhlP) and oxidative DNA-damage: results of a controlled human intervention trial
  • Konzumace kadeřavé kapusty chrání lidské periferní lymfocyty proti 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) a oxidativnímu poškození DNA: výsledek pokusu s podáním lidem (cs)
  • Consumption of Brussels sprouts protects peripheral human lymphocytes against 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhlP) and oxidative DNA-damage: results of a controlled human intervention trial (en)
skos:notation
  • RIV/61389030:_____/08:00319150!RIV09-AV0-61389030
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(1M0505), P(LC06004), Z(AV0Z50380511)
http://linked.open...iv/cisloPeriodika
  • 3
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 361110
http://linked.open...ai/riv/idVysledku
  • RIV/61389030:_____/08:00319150
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • antioxidant; comet assay; cruciferous vegetables; heterocyclic aromatic amines (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV
  • [46F3F7B282F6]
http://linked.open...i/riv/nazevZdroje
  • Molecular Nutrition & Food Research
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 52
http://linked.open...iv/tvurceVysledku
  • Angelis, Karel
  • Kundi, M.
  • Chakraborty, A.
  • Bichler, J.
  • Ferk, F.
  • Glatt, H.
  • Haidinger, G.
  • Hoelzl, C.
  • Knasmüller, S.
  • Meinl, W.
  • Nersesyan, A.
  • Simic, T.
  • Sontag, G.
http://linked.open...ain/vavai/riv/wos
  • 000254259500005
http://linked.open...n/vavai/riv/zamer
issn
  • 1613-4125
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