About: Synthesis and biological activity of olomoucine II.

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Based on our previous experiences with synthesis of purines, novel 2,6,9-trisubstituted purine derivatives were prepared and assayed for the ability to inhibit CDK1/cyclin B kinase. One of newly synthesized compounds designated as olomoucine II, 6-[(2-hydroxybenzyl)amino]-2-{[1-(hydroxymethyl)propyl]amino}-9-isopropylpurine, displays 10 times higher inhibitory activity than roscovitine, potent and specific CDK1 inhibitor. Olomoucine II in vitro cytotoxic activity exceeds purvalanol A, the most potent CDK inhibitor, as it kills the CEM cells with IC50 value of 3.0 micro M. Based on our previous experiences with synthesis of purines, novel 2,6,9-trisubstituted purine derivatives were prepared and assayed for the ability to inhibit CDK1/cyclin B kinase. One of newly synthesized compounds designated as olomoucine II, 6-[(2-hydroxybenzyl)amino]-2-{[1-(hydroxymethyl)propyl]amino}-9-isopropylpurine, displays 10 times higher inhibitory activity than roscovitine, potent and specific CDK1 inhibitor. Olomoucine II in vitro cytotoxic activity exceeds purvalanol A, the most potent CDK inhibitor, as it kills the CEM cells with IC50 value of 3.0 micro M. (en)
Title	Synthesis and biological activity of olomoucine II. Synthesis and biological activity of olomoucine II. (en)
skos:prefLabel	Synthesis and biological activity of olomoucine II. Synthesis and biological activity of olomoucine II. (en)
skos:notation	RIV/61389030:_____/02:56023048!RIV/2003/GA0/A56003/N
http://linked.open.../vavai/riv/strany	3283;3286
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA301/02/0475), P(OC 844.10), Z(AV0Z5020903), Z(AV0Z5038910)
http://linked.open...iv/cisloPeriodika	22
http://linked.open...vai/riv/dodaniDat	2003
http://linked.open...aciTvurceVysledku	Havlíček, Libor Kryštof, Vladimír Strnad, Miroslav
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav experimentální botaniky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	666105
http://linked.open...ai/riv/idVysledku	RIV/61389030:_____/02:56023048
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	purine; olomoucine II; purvalanol A (en)
http://linked.open.../riv/klicoveSlovo	purine olomoucine II purvalanol A
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[2165FC288625]
http://linked.open...i/riv/nazevZdroje	Bioorganic and Medicinal Chemistry Letters
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...vavai/riv/projekt	Purine inhibitors of cyclin-dependent kinases as anticancer and antimitotic compounds http://linked.opendata.cz/resource/domain/vavai/projekt/OC%20844.10
http://linked.open...UplatneniVysledku	2002
http://linked.open...v/svazekPeriodika	12
http://linked.open...iv/tvurceVysledku	Havlíček, Libor Kuzma, Marek Kryštof, Vladimír Strnad, Miroslav Lenobel, R.
http://linked.open...n/vavai/riv/zamer	Výzkum buněčné a molekulární biologie, genetiky, fyziologie a ekologie mikroorganizmů, mikrobní biotechnologie; studium imunitních procesů Physiological and genetical bases of plant development, cell cycle, morphogenesis, stress reactions and biotechnologies. Genome organisation and function
issn	0960-894X
number of pages	4 (xsd:int)

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