About: Effect of the purine derivative myoseverin and of its analogues on cultured hybridoma cells.

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About: Effect of the purine derivative myoseverin and of its analogues on cultured hybridoma cells. Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Two 2,6,9-trisubstituted purine derivatives, 9-isopropyl-2,6-bis[(4-methoxybenzyl)amino]-9H-purine (myoseverin, PMYO, 1) and 9-isopropyl-2,6-bis[(2-methoxybenzyl)amino]-9H-purine (OMYO, 2), and two 6,9-disubstituted derivatives, 9-isopropyl-6-[(4-methoxybenzyl)amino]-9H-purine (3) and 9-isopropyl-6-[(2-methoxybenzyl)amino]-9H-purine (4), were synthesized with the aim to examine their cell proliferation inhibiting activity, and possible additional effects in cultures of hybridoma cells producing monoclonal antibody. The substances were tested over a concentration range from 0.003 to 30 mmol l-1. The most active compound 1 caused a total loss of cell viability at 1 mmol l-1, while its isomer 2 showed the same effect at 10 mmol l-1 concentration. In the presence of compound 1, but not of compound 2, the character of the cell cycle phases profile changed dramatically, most cells being arrested in the G2/M phase. At intermediate concentrations of compound 2 a substantially higher viable cell concentration Two 2,6,9-trisubstituted purine derivatives, 9-isopropyl-2,6-bis[(4-methoxybenzyl)amino]-9H-purine (myoseverin, PMYO, 1) and 9-isopropyl-2,6-bis[(2-methoxybenzyl)amino]-9H-purine (OMYO, 2), and two 6,9-disubstituted derivatives, 9-isopropyl-6-[(4-methoxybenzyl)amino]-9H-purine (3) and 9-isopropyl-6-[(2-methoxybenzyl)amino]-9H-purine (4), were synthesized with the aim to examine their cell proliferation inhibiting activity, and possible additional effects in cultures of hybridoma cells producing monoclonal antibody. The substances were tested over a concentration range from 0.003 to 30 mmol l-1. The most active compound 1 caused a total loss of cell viability at 1 mmol l-1, while its isomer 2 showed the same effect at 10 mmol l-1 concentration. In the presence of compound 1, but not of compound 2, the character of the cell cycle phases profile changed dramatically, most cells being arrested in the G2/M phase. At intermediate concentrations of compound 2 a substantially higher viable cell concentration (en)
Title	Effect of the purine derivative myoseverin and of its analogues on cultured hybridoma cells. Effect of the purine derivative myoseverin and of its analogues on cultured hybridoma cells. (en)
skos:prefLabel	Effect of the purine derivative myoseverin and of its analogues on cultured hybridoma cells. Effect of the purine derivative myoseverin and of its analogues on cultured hybridoma cells. (en)
skos:notation	RIV/61389030:_____/02:56023045!RIV/2003/GA0/A56003/N
http://linked.open.../vavai/riv/strany	257;266
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA301/02/0475), P(GA303/02/0875), P(OC 844.10), Z(AV0Z5038910)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2003
http://linked.open...aciTvurceVysledku	Havlíček, Libor Franěk, František Siglerová, Věra Strnad, Miroslav
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav experimentální botaniky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	644354
http://linked.open...ai/riv/idVysledku	RIV/61389030:_____/02:56023045
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Purines; CDK Inhibitors; Cytokinins (en)
http://linked.open.../riv/klicoveSlovo	Cytokinins CDK Inhibitors Purines
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[BDCF9DC16C47]
http://linked.open...i/riv/nazevZdroje	Collection of Czechoslovak Chemical Communications
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...vavai/riv/projekt	Development of new generation of cyclin-dependent kinase inhibitors: structure-activity relationships, molecular and in vitro mechanisms of action Purine inhibitors of cyclin-dependent kinases as anticancer and antimitotic compounds http://linked.opendata.cz/resource/domain/vavai/projekt/OC%20844.10
http://linked.open...UplatneniVysledku	2002
http://linked.open...v/svazekPeriodika	67
http://linked.open...iv/tvurceVysledku	Eckschlager, T. Havlíček, Libor Strnad, Miroslav Franěk, František Siglerová, Věra Weigl, E.
http://linked.open...n/vavai/riv/zamer	Physiological and genetical bases of plant development, cell cycle, morphogenesis, stress reactions and biotechnologies. Genome organisation and function
issn	0010-0765
number of pages	10 (xsd:int)

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