About: Antiproliferative and Growth-stimulating Activities of Synthetic Cytokinin Analogs.

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About: Antiproliferative and Growth-stimulating Activities of Synthetic Cytokinin Analogs. Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Analogs of aromatic cytokinins, olomoucine, roscovitine, and bohemine, were screened for their capacity in supressing hybridoma cell growth and maintaining monoclonal antibody (MAb) production. Bohemine was selected as the most promising candidate for application. Addition of bohemine at concentrations in the range of 1-10 uM resulted in a short-term arrest of growth and of MAb secretion. The short-term suppression of cell functions was followed by a significant increase of specific growth rate and of specific production rate. At 3 uM bohemine concentration a moderate enhancement of MAb yield could be observed. The steady-state viable cell density values found in semicontinuous cultures showed stimulation of cell growth in the range of micromolar concentrations of bohemine, and inhibition of growth at higher concentrations. Analogs of aromatic cytokinins, olomoucine, roscovitine, and bohemine, were screened for their capacity in supressing hybridoma cell growth and maintaining monoclonal antibody (MAb) production. Bohemine was selected as the most promising candidate for application. Addition of bohemine at concentrations in the range of 1-10 uM resulted in a short-term arrest of growth and of MAb secretion. The short-term suppression of cell functions was followed by a significant increase of specific growth rate and of specific production rate. At 3 uM bohemine concentration a moderate enhancement of MAb yield could be observed. The steady-state viable cell density values found in semicontinuous cultures showed stimulation of cell growth in the range of micromolar concentrations of bohemine, and inhibition of growth at higher concentrations. (en)
Title	Antiproliferative and Growth-stimulating Activities of Synthetic Cytokinin Analogs. Antiproliferative and Growth-stimulating Activities of Synthetic Cytokinin Analogs. (en)
skos:prefLabel	Antiproliferative and Growth-stimulating Activities of Synthetic Cytokinin Analogs. Antiproliferative and Growth-stimulating Activities of Synthetic Cytokinin Analogs. (en)
skos:notation	RIV/61389030:_____/02:56023011!RIV/2003/GA0/A56003/N
http://linked.open.../vavai/riv/strany	315;319
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA301/02/0475), P(GA303/02/0875), P(OC 844.10), Z(AV0Z5038910)
http://linked.open...vai/riv/dodaniDat	2003
http://linked.open...aciTvurceVysledku	Havlíček, Libor Franěk, František Siglerová, Věra Strnad, Miroslav
http://linked.open.../riv/druhVysledku	C - Kapitola v knize
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav experimentální botaniky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	638593
http://linked.open...ai/riv/idVysledku	RIV/61389030:_____/02:56023011
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Cytokinin Analogs; Growth stimulating (en)
http://linked.open.../riv/klicoveSlovo	Cytokinin Analogs Growth stimulating
http://linked.open...ontrolniKodProRIV	[3ACA4B7505E0]
http://linked.open...i/riv/mistoVydani	NL
http://linked.open...vEdiceCisloSvazku	(1)
http://linked.open...i/riv/nazevZdroje	Animal Cell Technology - Basic and Applied Aspects.
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...vavai/riv/projekt	Development of new generation of cyclin-dependent kinase inhibitors: structure-activity relationships, molecular and in vitro mechanisms of action Purine inhibitors of cyclin-dependent kinases as anticancer and antimitotic compounds http://linked.opendata.cz/resource/domain/vavai/projekt/OC%20844.10
http://linked.open...UplatneniVysledku	2002
http://linked.open...iv/tvurceVysledku	Havlíček, Libor Strnad, Miroslav Franěk, František Siglerová, Věra
http://linked.open...n/vavai/riv/zamer	Physiological and genetical bases of plant development, cell cycle, morphogenesis, stress reactions and biotechnologies. Genome organisation and function
number of pages	5 (xsd:int)
http://purl.org/ne...btex#hasPublisher	Kluwer Academic Publishers
https://schema.org/isbn	0-7923-1882-X

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