About: Dendritic high-molecular-weight polymer drug carriers and their conjugates with drugs especially for treatment of solid tumours

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About: Dendritic high-molecular-weight polymer drug carriers and their conjugates with drugs especially for treatment of solid tumours Goto Sponge NotDistinct Permalink

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Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://worldwide.espacenet.com/publicationDetails/originalDocument?FT=D&date=20140226&DB=EPODOC&locale=en_EP&CC=EP&NR=2512521B1&KC=B1&ND=4
Description	The present invention relates to water-soluble high-molecular polymeric carriers of medicaments and their conjugates with medicaments, derived from dendrimers based on poly (amidoamine) and 2,2-bis(hydroxymethyl)propionic dendrimer, the amino and hydroxy end groups of which are attached to semitelechelic copolymers of N-(2 hydroxypropyl)methacrylamide (HPMA) through the mediation of biodegradable spacers. The polymer carriers and conjugates of the present invention enable targeted transport notably of anticancer medicaments into solid tumors in which biodegradation, the associated controlled drug release and subsequent elimination of polymer carrier from the organism are provided. The efficiency of the polymer carrier conjugated with a cancerostatic is directed to targeted therapy of human tumors. (en) The present invention relates to water-soluble high-molecular polymeric carriers of medicaments and their conjugates with medicaments, derived from dendrimers based on poly (amidoamine) and 2,2-bis(hydroxymethyl)propionic dendrimer, the amino and hydroxy end groups of which are attached to semitelechelic copolymers of N-(2 hydroxypropyl)methacrylamide (HPMA) through the mediation of biodegradable spacers. The polymer carriers and conjugates of the present invention enable targeted transport notably of anticancer medicaments into solid tumors in which biodegradation, the associated controlled drug release and subsequent elimination of polymer carrier from the organism are provided. The efficiency of the polymer carrier conjugated with a cancerostatic is directed to targeted therapy of human tumors.
Title	Dendritic high-molecular-weight polymer drug carriers and their conjugates with drugs especially for treatment of solid tumours Dendritic high-molecular-weight polymer drug carriers and their conjugates with drugs especially for treatment of solid tumours (en)
skos:prefLabel	Dendritic high-molecular-weight polymer drug carriers and their conjugates with drugs especially for treatment of solid tumours Dendritic high-molecular-weight polymer drug carriers and their conjugates with drugs especially for treatment of solid tumours (en)
skos:notation	RIV/61389013:_____/14:00438606!RIV15-AV0-61389013
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(IAA400500806), P(KAN200200651), Z(AV0Z40500505), Z(AV0Z50200510)
http://linked.open...cisloPatentuVzoru	EP2512521
http://linked.open...eleniPatentuVzoru	2014-02-26 (xsd:date)
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Strohalm, Jiří Ulbrich, Karel Chytil, Petr Etrych, Tomáš
http://linked.open.../riv/druhVysledku	P - Patent
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav makromolekulární chemie AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	10206
http://linked.open...ai/riv/idVysledku	RIV/61389013:_____/14:00438606
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	polymer conjugates; doxorubicin; drug targeting (en)
http://linked.open.../riv/klicoveSlovo	drug targeting doxorubicin polymer conjugates
http://linked.open...ontrolniKodProRIV	[118F1E28F455]
http://linked.open.../licencniPoplatek	A - Poskytovatel licence na výsledek požaduje licenční poplatek
http://linked.open...ydaniPatentuVzoru	Munich, The Hague, Berlin, Vienna, Brussels
http://linked.open...atelePatentuVzoru	Evropský patentový úřad
http://linked.open...in/vavai/riv/obor	CD
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Nanoparticulate and supramolecular systems for targeted drug delivery Branched and hyperbranched polymer carriers of drugs for local therapy
http://linked.open...UplatneniVysledku	2014
http://linked.open...iv/tvurceVysledku	Chytil, Petr Etrych, Tomáš Strohalm, Jiří Ulbrich, Karel Říhová, Blanka
http://linked.open...mniOchranaPatentu	A - EPO (Evropský patentový úřad)
http://linked.open...avai/riv/vlastnik	Ústav makromolekulární chemie AV ČR, v. v. i. - Mikrobiologický ústav AV ČR, v. v. i
http://linked.open...itiJinymSubjektem	A - Nabytí licence je nutné vždy
http://linked.open...uzitiPatentuVzoru	A - Pouze udělený nebo využívaný pouze vlastníkem
http://linked.open...n/vavai/riv/zamer	Progresivní makromolekulární materiály a supramolekulární systémy: syntéza a studium vlastností, jevů a možností využití pro speciální aplikace a moderní technologie Microorganisms in Research and Biotechnology
http://linked.open...stnikPatentuVzoru	Ústav makromolekulární chemie AV ČR, v. v. i. - Mikrobiologický ústav AV ČR, v. v. i

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