About: Synthesis, structural study, and in vitro trypanocidal and antitumour activities of tetrakis(3-methoxypropyl)tin and (3-methoxypropyl)tin chlorides.

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About: Synthesis, structural study, and in vitro trypanocidal and antitumour activities of tetrakis(3-methoxypropyl)tin and (3-methoxypropyl)tin chlorides. Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	A set of four water-soluble (3-methoxypropyl)stannanes of general formula (CH3OCH2CH2CH2)(x)SnCl4-x, where x = 4 (1), x = 3 (2), x = 2 (3), and x = 1 (4), was prepared. For 3 and 4, which were isolated in the crystalline state, it was shown by X-ray diffraction that the tin atom is coordinated in distorted octahedral and trigonal-bipyramidal geometries, respectively (i.e., the oxygen atoms of the 3-methoxypropyl groups were coordinated to the central tin atom in both cases, forming chelates). For all compounds, structures in CDCl3 and [D-6]DMSO solutions were proposed on the basis of their C-13 and Sn-119 NMR spectra. In CDCl3 solution, the degree of donor-acceptor bonding between the central tin atom and oxygen atom of the 3-methoxypropyl substituent was evaluated on the basis of O-17 NMR chemical shifts and 3,6J(H-1,Sn-119) long-range coupling constants. Compounds 2 and 3 exhibited promising antitumour and trypanocidal activities in vitro. A set of four water-soluble (3-methoxypropyl)stannanes of general formula (CH3OCH2CH2CH2)(x)SnCl4-x, where x = 4 (1), x = 3 (2), x = 2 (3), and x = 1 (4), was prepared. For 3 and 4, which were isolated in the crystalline state, it was shown by X-ray diffraction that the tin atom is coordinated in distorted octahedral and trigonal-bipyramidal geometries, respectively (i.e., the oxygen atoms of the 3-methoxypropyl groups were coordinated to the central tin atom in both cases, forming chelates). For all compounds, structures in CDCl3 and [D-6]DMSO solutions were proposed on the basis of their C-13 and Sn-119 NMR spectra. In CDCl3 solution, the degree of donor-acceptor bonding between the central tin atom and oxygen atom of the 3-methoxypropyl substituent was evaluated on the basis of O-17 NMR chemical shifts and 3,6J(H-1,Sn-119) long-range coupling constants. Compounds 2 and 3 exhibited promising antitumour and trypanocidal activities in vitro. (en)
Title	Synthesis, structural study, and in vitro trypanocidal and antitumour activities of tetrakis(3-methoxypropyl)tin and (3-methoxypropyl)tin chlorides. Synthesis, structural study, and in vitro trypanocidal and antitumour activities of tetrakis(3-methoxypropyl)tin and (3-methoxypropyl)tin chlorides. (en)
skos:prefLabel	Synthesis, structural study, and in vitro trypanocidal and antitumour activities of tetrakis(3-methoxypropyl)tin and (3-methoxypropyl)tin chlorides. Synthesis, structural study, and in vitro trypanocidal and antitumour activities of tetrakis(3-methoxypropyl)tin and (3-methoxypropyl)tin chlorides. (en)
skos:notation	RIV/61389013:_____/03:55033007!RIV/2004/AV0/A55004/N
http://linked.open.../vavai/riv/strany	143;148
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(LN00A028), Z(AV0Z4050913)
http://linked.open...iv/cisloPeriodika	N/A
http://linked.open...vai/riv/dodaniDat	2004
http://linked.open...aciTvurceVysledku	Brus, Jiří
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav makromolekulární chemie AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	630088
http://linked.open...ai/riv/idVysledku	RIV/61389013:_____/03:55033007
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	tin; chelates; O ligands (en)
http://linked.open.../riv/klicoveSlovo	chelates tin O ligands
http://linked.open...odStatuVydavatele	DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV	[79E0E8912FAF]
http://linked.open...i/riv/nazevZdroje	European Journal of Inorganic Chemistry
http://linked.open...in/vavai/riv/obor	BM
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...vavai/riv/projekt	New inorganic compounds and advanced materials
http://linked.open...UplatneniVysledku	2003
http://linked.open...v/svazekPeriodika	1
http://linked.open...iv/tvurceVysledku	Brus, Jiří Bruhn, C. Lébl, T. Smička, A.
http://linked.open...n/vavai/riv/zamer	Cílená syntéza a studium chemických, fyzikálně-chemických a fyzikálních vlastností makromolekulárních a nadmolekulárních látek a soustav pro vyspělé technologie
issn	1434-1948
number of pages	6 (xsd:int)

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