About: Decreased binding to proteins and cells of polymeric gene delivery vectors surface modified with a multivalent hydrophilic polymer and retargeting through attachment of transferrin.

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About: Decreased binding to proteins and cells of polymeric gene delivery vectors surface modified with a multivalent hydrophilic polymer and retargeting through attachment of transferrin. Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	A multivalent reactive hydrophilic polymer (pHPMA ) was used to inhibit protein binding to polyelectrolyte gene delivery complexes. pHPMA-coated complexes are completely resistant to protein interaction, as determined by turbidometry and SDS-polyacrylamide gel electrophoresis of complexes isolated from plasma, and show significantly decreased nonspecific uptake into cells in vitro. A multivalent reactive hydrophilic polymer (pHPMA ) was used to inhibit protein binding to polyelectrolyte gene delivery complexes. pHPMA-coated complexes are completely resistant to protein interaction, as determined by turbidometry and SDS-polyacrylamide gel electrophoresis of complexes isolated from plasma, and show significantly decreased nonspecific uptake into cells in vitro. (en)
Title	Decreased binding to proteins and cells of polymeric gene delivery vectors surface modified with a multivalent hydrophilic polymer and retargeting through attachment of transferrin. Decreased binding to proteins and cells of polymeric gene delivery vectors surface modified with a multivalent hydrophilic polymer and retargeting through attachment of transferrin. (en)
skos:prefLabel	Decreased binding to proteins and cells of polymeric gene delivery vectors surface modified with a multivalent hydrophilic polymer and retargeting through attachment of transferrin. Decreased binding to proteins and cells of polymeric gene delivery vectors surface modified with a multivalent hydrophilic polymer and retargeting through attachment of transferrin. (en)
skos:notation	RIV/61389013:_____/00:55000056!RIV/2003/AV0/A55003/N
http://linked.open.../vavai/riv/strany	3793;3802
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GV307/96/K226), Z(AV0Z4050913)
http://linked.open...iv/cisloPeriodika	6
http://linked.open...vai/riv/dodaniDat	2003
http://linked.open...aciTvurceVysledku	Strohalm, Jiří Ulbrich, Karel Šubr, Vladimír Oupický, David
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav makromolekulární chemie AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	708111
http://linked.open...ai/riv/idVysledku	RIV/61389013:_____/00:55000056
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	N/A (en)
http://linked.open.../riv/klicoveSlovo	N/A
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[A087B1919571]
http://linked.open...i/riv/nazevZdroje	Journal of Biological Chemistry
http://linked.open...in/vavai/riv/obor	CD
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	10 (xsd:int)
http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...vavai/riv/projekt	New macromolecular systems for targeted delivery of biological active compounds in the living organism
http://linked.open...UplatneniVysledku	2000
http://linked.open...v/svazekPeriodika	275
http://linked.open...iv/tvurceVysledku	Strohalm, Jiří Ulbrich, Karel Fisher, K. D. Seymour, L. W. Šubr, Vladimír Dash, P. R. Wolfert, M. A. Oupický, David Read, M. L. Howard, K. A.
http://linked.open...n/vavai/riv/zamer	Cílená syntéza a studium chemických, fyzikálně-chemických a fyzikálních vlastností makromolekulárních a nadmolekulárních látek a soustav pro vyspělé technologie
issn	0021-9258
number of pages	10 (xsd:int)

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