About: New macromolecular systems for targeted delivery of biological active compounds in the living organism

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Projekt, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/domain/vavai/Projekt
rdfs:seeAlso	http://www.isvav.cz/projectDetail.do?rowId=GV307/96/K226
Description	Based on successful feasibility studies in the past years it is proposed to study new polymeric systems for site-specific delivery of biologically active substances (BAS). These are composed of a water soluble polymeric carrier to which BAS and the tergeting moiety are conjugated by enzymatically or hydrolytically cleavable bonds. Following different drug-carrier systems will be compared 1) %22classical%22 N-(2-hydroxypropyl)-methacrylamide (HPMA) copolymers with biodegradable oligopeptide side chains2) %22star-like conjugates%22 where several polymer molecules or polymers containing drug are linked to the targeting moiety via theirs terminal amino or carboxylic group, 3) biodegradable %22block%22 copolymers of polyethylenglycol (PEG) and 4) block copolymersof polycations with hydrophilic polymers. We propose to compare the effectiveness of these drug delivery systems in the treatment of cancer and/or graft-versus-host disease (GVHD). The project is interdisciplinary, involving organic, polymer and physical (en) Na základě předchozích zkušeností a výsledků navrhujeme sledovat nejmodernější trendy ve vývoji léčiv a studovat systémy umožňující cílený transport a řízené uvolňování biologicky aktivních látek (BAL) v živém organismu. Základem navrhovaných systémů je vodorozpustný polymerní nosič, ke kterému jsou hydrolyticky nebo enzymaticky štěpitelnou vazbou připojeny molekuly BAL a specifické směřující jednotky. Budou studovány následující systémy: 1) %22klasické%22 kopolymery N-2(hydroxypropyl)metakrylamidu (HPMA), obsahující biodegradovatelné olifopeptidové postranní řetězce, 2) %22hvězdicové%22 konjugáty, ve kterých jsou molekuly polymeru, nesoucího léčivo, připojeny k centrální molekule směřující jednotky (protilátky) pomocí koncových amino nebo karboxylových skupin3) biodegradovatelné %22blokové%22 kopolymery polyethylenglykolu (PEG) a 4) blokové kopolymery polykationtů s hydrofilními polymery. Navrhujeme porovnat efektivitu účinsku těchto systémů použitých jako nosiče protirakovinových léčiv a imunosupresiv (GVHD). P
Title	New macromolecular systems for targeted delivery of biological active compounds in the living organism (en) Nové makromolekulární systémy pro cílený transport biologicky aktivních látek v živém organizmu
skos:notation	GV307/96/K226
http://linked.open...avai/cep/aktivita	Comprehensive projects
http://linked.open...kovaStatniPodpora	http://linked.opendata.cz/resource/domain/vavai/projekt/GV307%2F96%2FK226/celkovaStatniPodpora
http://linked.open...ep/celkoveNaklady	http://linked.opendata.cz/resource/domain/vavai/projekt/GV307%2F96%2FK226/celkoveNaklady
http://linked.open...datumDodatniDoRIV	2002-11-19 (xsd:date)
http://linked.open...i/cep/druhSouteze	VS - Veřejná soutěž ve výzkumu a vývoji
http://linked.open...ep/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open.../cep/fazeProjektu	877068
http://linked.open...ai/cep/hlavniObor	CD - Makromolekulární chemie
http://linked.open...hodnoceniProjektu	V - Vynikající výsledky (s mezinárodním významem apod.). Zároveň byly splněny cíle a předpokládané výsledky uvedené ve smlouvě / rozhodnutí o poskytnutí podpory.
http://linked.open.../cep/klicovaSlova	Neuvedeno. (en)
http://linked.open...ep/partnetrHlavni	Ústav makromolekulární chemie AV ČR, v. v. i.
http://linked.open...inujicichPrijemcu	0 (xsd:int)
http://linked.open...cep/pocetPrijemcu	1 (xsd:int)
http://linked.open...ocetSpoluPrijemcu	3 (xsd:int)
http://linked.open.../pocetVysledkuRIV	138 (xsd:int)
http://linked.open...enychVysledkuVRIV	138 (xsd:int)
http://linked.open...iciPoslednihoRoku	2002
http://linked.open...atUdajeProjZameru	2002
http://linked.open...usZobrazovaneFaze	DUU
http://linked.open...ai/cep/typPojektu	P - Projekt výzkumu a vývoje financovaný ze státního rozpočtu
http://linked.open.../cep/vedlejsiObor	FR - Farmakologie a lékárnická chemie ED - Fyziologie
http://linked.open...jektu+dodavatelem	Vynikající práce velmi dobře zpracovaná a dokumentovaná. Údaje v Závěrečné kartě jsou adekvátní. Práce má přímý význam pro klinickou aplikaci makromolekulárních systémů pro cílený transport aktivních látek. Výstupy jsou abudandní, zahrnují 49 publikací i (cs)
http://linked.open...tniCyklusProjektu	ZBBBBKU
is http://linked.open...vavai/riv/projekt of	Enzymatically degradable peg multiblock copolymers with hydrazone-attached doxorubicin in cancer therapy. Glia and Extracellular Space Diffusion Parameters in the Injured and Aging Brain. Glial diffusion barriers during aging and pathological states. Two patients with breast carcinoma treated with Ig-G targeted HPMA-DOX: Clinical and experimental findings Two patients with breast carcinoma treated with IgG-targeted MPMA-dox: clinical and experimental findings. Polymer-conjugated bovine pancreatic and seminal ribonucleases inhibit growth of human tumors in nude mice HPMA-based hydrogels for anti-cancer therapy. HPMA-based hydrogels for anti-cancer therapy. Ischemia-induced changes in the extracellular space diffusion parameters, K+ and pH in the developing rat cortex and corpus callosum. Polymer conjugates of bovine seminal ribonuclease for cance therapy. Polymeric carriers of drugs from site-specific therapy. Poly/N-(2-hydroxypropyl)methacrylamide/ conjugates of methotrexate. Synthesis and in vivo drug release. N/A Enzymatically degradable drug carrier system based on poly(ethylene glycol) multiblock copolymers. Computing of cathepsin B - drug interaction. Difusion constraints and neuron-glia interaction dduring aging. Micellization of graft copolymers of alkyl methacrylates with .alfa.-methyl-.infin.-hydroxypoly(oxyethylene) methacrylates. Receptor-mediated targeted drug or toxin delivery. The using of targetable drugs in intitumor and immunosupression therapy. Conjugates of semitelechelic poly[N-(2-hydroxypropyl)methacrylamide] with enzymes for protein delivery. Computer-aided modelling of enzyme - subtrate interaction. DNA complexes with block and graft copolymers of N-(2-hydroxypropyl)methacrylamide and 2-trimethylammonio)ethyl methacrylate. Conjugates of semitelechelic poly[N-(2-hydroxypropyl)methacrylamide] with enzymes for protein delivery. Effect of albumin and polyanion on the structure of DNA complexes wtih polycation containing hydrophilic nonionic block. Comparative histochemical and biochemical studies on acid beta-galactosidase activity in the experimentally injured rabbit cornea and tear fluid using the sensitive substrate beta-galactoside-4-trifluoromethylumbelliferyl (HFC). Diffusion Barriers Evoked in the Rat Cortex by Reactive Astrogliosis. Preparation of DNA complexes with diblock copolymers of poly[N(2-hydroxypropyl)methacryalamide] and polycations. Polyelectrolyte vectors for gene delivery: influence of cationic polymer on biophysical properties of complexes formed with DNA. Počítačové molekulární modelování a simulace: Perspektivy a hranice použití. Synthesis of macromolecular conjugates of a urokinase inhibitor: amiloride. Bovine seminal ribonuclease inhibits in vivo growth of human neuroblastoma cells. Changes of superoxide dismutase, catalase and glutathione peroxidase in the corneal epithelium after UVB rays. Histochemical and biochemical study. Extracellular diffusion parametrs in spinal cord and filum terminale of the frog. Hydrophilic polymers for drug delivery. Influence of hydrophilicity of cationic polymers on the biophysical properties of polyelectrolyte complexes formed by self-assembly with DNA. Glial influence on neuronal signaling. Extracellular space diffusion and pathological states. Extracellular Diffusion Parameters in Spinal Cord and Filum Terminale of the Frog. Glial diffusion barriers during aging and pathological states. Extracellular space diffusion parameters in human cortex and gliomas. Extracellular space diffusion parameters in tissue slices of human cortex and glial tumors. Extracellular matrix and diffusion barriers in the extracellular space. The favourable effect of hindered amines light stabilizers (HALS) on the healing of skin wounds. Extracellular space volume fraction and geometry in human cortex and gliomas. Glial cells and volume transmission in the CNS. New HPMA copolymers containing doxorubicin bound via pH-sensitive linkage: synthesis and preliminary in vitro and in vivo biological properties. Neuron-glia communication by extrasynaptic transmission. Reactive oxygen species (ROS)-generating oxidases in the normal rabbit cornea and their involvement in the corneal damage evoked by UVB rays. Acquired and specific imunological mechanisms co-responsible for efficacy of polymer-bound drugs Computer modelling of 5-fluorouracil conjugate with an N-(2-hydroxypropyl)methacrylamide copolymer in an active cleft of the cathepsin B. Detection and cellular localisation of the synthetic soluble macromolecular drug carrier pHPMA. HPMA hydrogel systems for controlled release of drugs and their combinations HPMA copolymer-bound doxorubicin conjugates containing either non-specific IgG or monoclonal antibody for targeting: comparison of anti-tumor acitivity on BCL1 leukemia and on 38C13 lymphoma Novel generation of polymer-drug-carrier systems for site-specific therapy. Specificity of antibody-targeted drugs. Specificity of antibody-targeted drugs. Solution and photoproperties of N-(2-hydroxypropyl)methacrylamide copolymer-meso-chlorin e6 conjugates. Synthesis of biodegradable polymers for controlled drug release. The status and organization of astrocytes, oligodendroglia and microglia in grafts of fetal rat cerebral cortex. CAMM of anticancer drugs. The appearance and possible role of plasminogen activator of urokinase type (u-PA) activity in the cornea related to soft contact lens wear in rabbit. Use of 'star-like' macromolecular prodrugs in cancer therapy. Thermally controlled association in aqueous solutions of diblock copolymers of poly (N-(2-hydroxypropyl)methacrylamide) and poly(N-isoprolylacrylamide). Tři přístupy k počítačovému modelování struktury a interakcí velkých molekul. Swelling and membrane properties of astrocytes in spinal cord of GEAP - deficient mice. Acquired and specific immunological mechanisms coresponsible for efficacy of polymer-bound drug. Antibody-targeted polymer conjugates of drugs. Polymer conjugates of bovine pancreatic ribonuclease (RNase A) for cancer therapy. Polymer conjugates of bovine pancreatic ribonuclease, RNase A for vcancer therapy

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