About: New HPMA copolymers containing doxorubicin bound via pH-sensitive linkage: synthesis and preliminary in vitro and in vivo biological properties.

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About: New HPMA copolymers containing doxorubicin bound via pH-sensitive linkage: synthesis and preliminary in vitro and in vivo biological properties. Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	This paper describe the synthesis, physico-chemical characteristics and results of biological tests of polymer drug based on conjugates of anti-cancer drug doxorubicin with N-(2-hydroxypropyl)methacrylamide copolymers. In the conjugates the drug is attached to the polymer via a spacer stable under physiological conditions and hydrolytically degradable in mild acidic environment. This paper describe the synthesis, physico-chemical characteristics and results of biological tests of polymer drug based on conjugates of anti-cancer drug doxorubicin with N-(2-hydroxypropyl)methacrylamide copolymers. In the conjugates the drug is attached to the polymer via a spacer stable under physiological conditions and hydrolytically degradable in mild acidic environment. (en)
Title	New HPMA copolymers containing doxorubicin bound via pH-sensitive linkage: synthesis and preliminary in vitro and in vivo biological properties. New HPMA copolymers containing doxorubicin bound via pH-sensitive linkage: synthesis and preliminary in vitro and in vivo biological properties. (en)
skos:prefLabel	New HPMA copolymers containing doxorubicin bound via pH-sensitive linkage: synthesis and preliminary in vitro and in vivo biological properties. New HPMA copolymers containing doxorubicin bound via pH-sensitive linkage: synthesis and preliminary in vitro and in vivo biological properties. (en)
skos:notation	RIV/61389013:_____/01:55010237!RIV/2003/AV0/A55003/N
http://linked.open.../vavai/riv/strany	89;102
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA307/96/0996), P(GV307/96/K226), P(KSK2055603), P(PZ-Z2/24), Z(AV0Z4050913), Z(AV0Z5020903)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2003
http://linked.open...aciTvurceVysledku	Ulbrich, Karel Etrych, Tomáš
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav makromolekulární chemie AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	688748
http://linked.open...ai/riv/idVysledku	RIV/61389013:_____/01:55010237
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	N-(2-hydroxypropyl)methacrylamide copolymers; drug delivery; doxorubicin (en)
http://linked.open.../riv/klicoveSlovo	N-(2-hydroxypropyl)methacrylamide copolymers doxorubicin drug delivery
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[63950A295FED]
http://linked.open...i/riv/nazevZdroje	Journal of Controlled Release
http://linked.open...in/vavai/riv/obor	FR
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...vavai/riv/projekt	Biorecognizable polymer conjugates with anticancer activity. Structure - pharmacological activity relationship of platinum and ruthenium complexes New macromolecular systems for targeted delivery of biological active compounds in the living organism Chemistry for application in biology and medicine
http://linked.open...UplatneniVysledku	2001
http://linked.open...v/svazekPeriodika	73
http://linked.open...iv/tvurceVysledku	Etrych, Tomáš Ulbrich, Karel Říhová, Blanka Jelínková, Markéta
http://linked.open...n/vavai/riv/zamer	Cílená syntéza a studium chemických, fyzikálně-chemických a fyzikálních vlastností makromolekulárních a nadmolekulárních látek a soustav pro vyspělé technologie Výzkum buněčné a molekulární biologie, genetiky, fyziologie a ekologie mikroorganizmů, mikrobní biotechnologie; studium imunitních procesů
issn	0168-3659
number of pages	14 (xsd:int)

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