| Attributes | Values |
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| rdf:type
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| Description
| - Byla studována úloha mitochondriální glycerofosfát dehydrogenázy (mGPDH, EC 1.1.99.5) při tvorbě reaktivních sloučenin kyslíku (ROS) v mitochondriích hnědé tukové tkáně pomocí různých spektroskopických metod. Použití inhibitorů respiračního řetězce antimycinu A a myxothiazolu prokázalo, že v případě oxidace glycerofosfátu pochází většina ROS přímo z mGPDH a koenzymu Q, zatímco komplex III byl hlavním producentem ROS při oxidaci sukcinátu. Byly pozorovány zřetelné rozdíly v mechanismu ROS produkce při oxidaci glycerofosfátu vs. sukcinátu, které naznačují, že přenos elektronů z mGPDH na koenzym Q je vysoce náchylný k úniku elektronů a tvorbě superoxidu (cs)
- Role of mitochondrial glycerophosphate dehydrogenase (mGPDH, EC 1.1.99.5) in reactive oxygen species (ROS) production was studied in brown adipose tissue mitochondria by different spectroscopic techniques. Use of respiratory chain inhibitors antimycin A and myxothiazol revealed that in case of glycerophosphate oxidation, most of the ROS originated directly from mGPDH and coenzyme Q while complex III was a typical site of ROS production in succinate oxidation. Collectively, there are pronounced differences in the mechanism of ROS production originating from oxidation of glycerophosphate and succinate indicating that electron transfer from mGPDH to coenzyme Q is highly prone to electron leak and superoxide generation
- Role of mitochondrial glycerophosphate dehydrogenase (mGPDH, EC 1.1.99.5) in reactive oxygen species (ROS) production was studied in brown adipose tissue mitochondria by different spectroscopic techniques. Use of respiratory chain inhibitors antimycin A and myxothiazol revealed that in case of glycerophosphate oxidation, most of the ROS originated directly from mGPDH and coenzyme Q while complex III was a typical site of ROS production in succinate oxidation. Collectively, there are pronounced differences in the mechanism of ROS production originating from oxidation of glycerophosphate and succinate indicating that electron transfer from mGPDH to coenzyme Q is highly prone to electron leak and superoxide generation (en)
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| Title
| - Respiratory chain components involved in the glycerophosphate dehydrogenase-dependent ROS production by brown adipose tissue mitochondria
- Komponenty respiračního řetězce zúčastněné v glycerofosfát dehydrogenáza-dependentní tvorbě ROS v mitochondriích hnědé tukové tkáně (cs)
- Respiratory chain components involved in the glycerophosphate dehydrogenase-dependent ROS production by brown adipose tissue mitochondria (en)
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| skos:prefLabel
| - Respiratory chain components involved in the glycerophosphate dehydrogenase-dependent ROS production by brown adipose tissue mitochondria
- Komponenty respiračního řetězce zúčastněné v glycerofosfát dehydrogenáza-dependentní tvorbě ROS v mitochondriích hnědé tukové tkáně (cs)
- Respiratory chain components involved in the glycerophosphate dehydrogenase-dependent ROS production by brown adipose tissue mitochondria (en)
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| skos:notation
| - RIV/61388980:_____/07:00087238!RIV08-GA0-61388980
|
| http://linked.open.../vavai/riv/strany
| |
| http://linked.open...avai/riv/aktivita
| |
| http://linked.open...avai/riv/aktivity
| - P(1M0520), P(GA303/06/1261), R, Z(AV0Z40320502), Z(AV0Z50110509)
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| http://linked.open...iv/cisloPeriodika
| |
| http://linked.open...vai/riv/dodaniDat
| |
| http://linked.open...aciTvurceVysledku
| |
| http://linked.open.../riv/druhVysledku
| |
| http://linked.open...iv/duvernostUdaju
| |
| http://linked.open...titaPredkladatele
| |
| http://linked.open...dnocenehoVysledku
| |
| http://linked.open...ai/riv/idVysledku
| - RIV/61388980:_____/07:00087238
|
| http://linked.open...riv/jazykVysledku
| |
| http://linked.open.../riv/klicovaSlova
| - brown adipose tissue mitochondria; reactive oxygen species; glycerophosphate dehydrogenase, (en)
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| http://linked.open.../riv/klicoveSlovo
| |
| http://linked.open...odStatuVydavatele
| |
| http://linked.open...ontrolniKodProRIV
| |
| http://linked.open...i/riv/nazevZdroje
| - Biochimica Et Biophysica Acta-Bioenergetics
|
| http://linked.open...in/vavai/riv/obor
| |
| http://linked.open...ichTvurcuVysledku
| |
| http://linked.open...cetTvurcuVysledku
| |
| http://linked.open...vavai/riv/projekt
| |
| http://linked.open...UplatneniVysledku
| |
| http://linked.open...v/svazekPeriodika
| |
| http://linked.open...iv/tvurceVysledku
| - Stopka, Pavel
- Drahota, Zdeněk
- Houštěk, Josef
- Vrbacký, Marek
- Ješina, Pavel
- Mráček, Tomáš
- Vojtíšková, Alena
|
| http://linked.open...n/vavai/riv/zamer
| |
| issn
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| number of pages
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| is http://linked.open...avai/riv/vysledek
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