About: Does exogenous melatonin influence the free radicals metabolism and pain sensation in rat?

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Melatonin has been shown to play a role in antioxidative defence. We therefore studied its effect on oxidative damage to the rat cerebral cortex evoked by painful stimulation and immobilization-induced stress. Moreover, the effect of melatonin on chronic pain perception was examined. Rats were injected with either a high dose of melatonin (100 mg/kg i.p.) or a vehicle for five days and were subjected to painful stimulation or immobilization stress 30 min after the treatment. To determine the degree of oxidative stress, the levels of free radicals, thiobarbituric acid reactive substances (TBARS) as indicators of lipid peroxidation and glutathione peroxidase (GSHPx) were estimated in somatosensory cortex. Pain perception was measured by the tail-flick and plantar test. Melatonin reduced the level of TBARS previously increased by painful stimulation. Melatonin also exhibited a slight analgesic effect in those animals exposed to painful stimulation but its role in free radical scavenging did not contribut Melatonin has been shown to play a role in antioxidative defence. We therefore studied its effect on oxidative damage to the rat cerebral cortex evoked by painful stimulation and immobilization-induced stress. Moreover, the effect of melatonin on chronic pain perception was examined. Rats were injected with either a high dose of melatonin (100 mg/kg i.p.) or a vehicle for five days and were subjected to painful stimulation or immobilization stress 30 min after the treatment. To determine the degree of oxidative stress, the levels of free radicals, thiobarbituric acid reactive substances (TBARS) as indicators of lipid peroxidation and glutathione peroxidase (GSHPx) were estimated in somatosensory cortex. Pain perception was measured by the tail-flick and plantar test. Melatonin reduced the level of TBARS previously increased by painful stimulation. Melatonin also exhibited a slight analgesic effect in those animals exposed to painful stimulation but its role in free radical scavenging did not contribut (en)
Title	Does exogenous melatonin influence the free radicals metabolism and pain sensation in rat? Does exogenous melatonin influence the free radicals metabolism and pain sensation in rat? (en)
skos:prefLabel	Does exogenous melatonin influence the free radicals metabolism and pain sensation in rat? Does exogenous melatonin influence the free radicals metabolism and pain sensation in rat? (en)
skos:notation	RIV/61388980:_____/01:50033024!RIV/2004/MZ0/A50004/N
http://linked.open.../vavai/riv/strany	595;602
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(NB6728), P(NE6738), P(NF4665), Z(AV0Z4032918), Z(MSM 111400002)
http://linked.open...iv/cisloPeriodika	6
http://linked.open...vai/riv/dodaniDat	2004
http://linked.open...aciTvurceVysledku	Stopka, Pavel
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav anorganické chemie AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	678076
http://linked.open...ai/riv/idVysledku	RIV/61388980:_____/01:50033024
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	melatonin; oxidative stress; pain stress (en)
http://linked.open.../riv/klicoveSlovo	melatonin oxidative stress pain stress
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[B1FD7FB3747E]
http://linked.open...i/riv/nazevZdroje	Physiological Reserch
http://linked.open...in/vavai/riv/obor	CA
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...vavai/riv/projekt	The impact of enteral nutrition on hepatosplanchnic blood flow and metabolism in critically ill septic patients. Lipid Metabolism and Oxidative Stress Parameters in Perinatal Period with Respect of Their Therapeutic Influence and Monitoring The role and mechanism of action of free radicals in the pathogenesis and therapy of the pain.
http://linked.open...UplatneniVysledku	2001
http://linked.open...v/svazekPeriodika	50
http://linked.open...iv/tvurceVysledku	Rokyta, R. Stopka, Pavel Racek, J. Trefil, L. Holeček, V. Parara, S. Pekárková, I.
http://linked.open...n/vavai/riv/zamer	Synthesis and structure of novel (inorganic) compounds, clusters and composites; mechanisms of conversion and transfer in systems involving inorganic substance http://linked.opendata.cz/resource/domain/vavai/zamer/MSM%20111400002
issn	0862-8408
number of pages	8 (xsd:int)

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