About: Membrane Transport Inhibition as Mode of Action of Polyene Antimycotics: Recent Data Supported by Old Ones

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Recent studies demonstrate that the actual interactions of polyenes with membrane sterols are the basis for their antimycotic toxicity and not, as previously assumed, their potential to form pores. Therefore, sterols must play a vital role in membranes and this function is seriously disturbed once polyenes bind to and/or sequester them. Essential membrane proteins obviously require sterols for their activity. Among the various membrane. protein/ergosterol interactions discussed herein, transport proteins of the plasma membrane are most likely the primary target for polyenes. All data available which support this notion are summarized in this review. Even data obtained almost 40 years ago could be useful in guiding future research Recent studies demonstrate that the actual interactions of polyenes with membrane sterols are the basis for their antimycotic toxicity and not, as previously assumed, their potential to form pores. Therefore, sterols must play a vital role in membranes and this function is seriously disturbed once polyenes bind to and/or sequester them. Essential membrane proteins obviously require sterols for their activity. Among the various membrane. protein/ergosterol interactions discussed herein, transport proteins of the plasma membrane are most likely the primary target for polyenes. All data available which support this notion are summarized in this review. Even data obtained almost 40 years ago could be useful in guiding future research (en)
Title	Membrane Transport Inhibition as Mode of Action of Polyene Antimycotics: Recent Data Supported by Old Ones Membrane Transport Inhibition as Mode of Action of Polyene Antimycotics: Recent Data Supported by Old Ones (en)
skos:prefLabel	Membrane Transport Inhibition as Mode of Action of Polyene Antimycotics: Recent Data Supported by Old Ones Membrane Transport Inhibition as Mode of Action of Polyene Antimycotics: Recent Data Supported by Old Ones (en)
skos:notation	RIV/61388971:_____/14:00428442!RIV15-GA0-61388971
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GAP305/12/0480), Z(AV0Z50200510)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Opekarová, Miroslava
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Mikrobiologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	28260
http://linked.open...ai/riv/idVysledku	RIV/61388971:_____/14:00428442
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	amphotericin B; nystatin; natamycin (en)
http://linked.open.../riv/klicoveSlovo	natamycin amphotericin B nystatin
http://linked.open...odStatuVydavatele	HR - Chorvatská republika
http://linked.open...ontrolniKodProRIV	[291DB760BDD8]
http://linked.open...i/riv/nazevZdroje	Food Technology and Biotechnology
http://linked.open...in/vavai/riv/obor	EE
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	2 (xsd:int)
http://linked.open...vavai/riv/projekt	Heat-induced stress granules in yeast
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	52
http://linked.open...iv/tvurceVysledku	Opekarová, Miroslava Tanner, W.
http://linked.open...ain/vavai/riv/wos	000333884700003
http://linked.open...n/vavai/riv/zamer	Microorganisms in Research and Biotechnology
issn	1330-9862
number of pages	5 (xsd:int)

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