About: Patterns of Early Gut Colonization Shape Future Immune Responses of the Host

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The most important trigger for immune system development is the exposure to microbial components immediately after birth. Moreover, targeted manipulation of the microbiota can be used to change host susceptibility to immune-mediated diseases. Our aim was to analyze how differences in early gut colonization patterns change the composition of the resident microbiota and future immune system reactivity. Germ-free (GF) mice were either inoculated by single oral gavage of caecal content or let colonized by co-housing with specific pathogen-free (SPF) mice at different time points in the postnatal period. The microbiota composition was analyzed by denaturing gradient gel electrophoresis for 16S rRNA gene followed by principal component analysis The most important trigger for immune system development is the exposure to microbial components immediately after birth. Moreover, targeted manipulation of the microbiota can be used to change host susceptibility to immune-mediated diseases. Our aim was to analyze how differences in early gut colonization patterns change the composition of the resident microbiota and future immune system reactivity. Germ-free (GF) mice were either inoculated by single oral gavage of caecal content or let colonized by co-housing with specific pathogen-free (SPF) mice at different time points in the postnatal period. The microbiota composition was analyzed by denaturing gradient gel electrophoresis for 16S rRNA gene followed by principal component analysis (en)
Title	Patterns of Early Gut Colonization Shape Future Immune Responses of the Host Patterns of Early Gut Colonization Shape Future Immune Responses of the Host (en)
skos:prefLabel	Patterns of Early Gut Colonization Shape Future Immune Responses of the Host Patterns of Early Gut Colonization Shape Future Immune Responses of the Host (en)
skos:notation	RIV/61388971:_____/12:00378860!RIV13-AV0-61388971
http://linked.open...avai/predkladatel	Mikrobiologický ústav AV ČR, v.v.i.
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(AV0Z50200510)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Hudcovic, Tomáš Tlaskalová-Hogenová, Helena Kverka, Miloslav Klimešová, Klára Zákostelská, Zuzana
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Mikrobiologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	157989
http://linked.open...ai/riv/idVysledku	RIV/61388971:_____/12:00378860
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	SEGMENTED FILAMENTOUS BACTERIA; REGULATORY T-CELLS; MICROBIOTA (en)
http://linked.open.../riv/klicoveSlovo	MICROBIOTA REGULATORY T-CELLS SEGMENTED FILAMENTOUS BACTERIA
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[87251ADEA564]
http://linked.open...i/riv/nazevZdroje	PLoS ONE
http://linked.open...in/vavai/riv/obor	EC
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	7
http://linked.open...iv/tvurceVysledku	Tlaskalová-Hogenová, Helena Hansen, A. K. Hudcovic, Tomáš Klimešová, Klára Kverka, Miloslav Zákostelská, Zuzana Hansen, C. H. F. Nielsen, D. S.
http://linked.open...ain/vavai/riv/wos	000303894900058
http://linked.open...n/vavai/riv/zamer	Microorganisms in Research and Biotechnology
issn	1932-6203
number of pages	7 (xsd:int)
http://bibframe.org/vocab/doi	10.1371/journal.pone.0034043
is http://linked.open...avai/riv/vysledek of	Patterns of Early Gut Colonization Shape Future Immune Responses of the Host

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