About: Neonatal colonization of mice with probiotic bacteria: Impact on systemic sensitization to aeroallergen Bet v 1

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Mono-colonization of mice with the Bet v 1 producing L. plantarum induced a Th1-biased immune response at the cellular level and reduced levels of Bet v 1 specific antibodies in sera, while wild type strain had no such effect. On the other hand, B. longum strain supressed cytokine production as well as specific antibody production. In vitro we showed different immunomodulatory properties of these two strains with different signalling through TLR receptors. We speculate that strong Th1 inducers like L. plantarum are able to modulate the systemic sensitization in vivo only when administrated together with the allergen. On the other hand, moderately stimulating probiotics such as B. longum ssp. longum are able to suppress the sensitization in a different way by inducing Treg bias Mono-colonization of mice with the Bet v 1 producing L. plantarum induced a Th1-biased immune response at the cellular level and reduced levels of Bet v 1 specific antibodies in sera, while wild type strain had no such effect. On the other hand, B. longum strain supressed cytokine production as well as specific antibody production. In vitro we showed different immunomodulatory properties of these two strains with different signalling through TLR receptors. We speculate that strong Th1 inducers like L. plantarum are able to modulate the systemic sensitization in vivo only when administrated together with the allergen. On the other hand, moderately stimulating probiotics such as B. longum ssp. longum are able to suppress the sensitization in a different way by inducing Treg bias (en)
Title	Neonatal colonization of mice with probiotic bacteria: Impact on systemic sensitization to aeroallergen Bet v 1 Neonatal colonization of mice with probiotic bacteria: Impact on systemic sensitization to aeroallergen Bet v 1 (en)
skos:prefLabel	Neonatal colonization of mice with probiotic bacteria: Impact on systemic sensitization to aeroallergen Bet v 1 Neonatal colonization of mice with probiotic bacteria: Impact on systemic sensitization to aeroallergen Bet v 1 (en)
skos:notation	RIV/61388971:_____/11:00375208!RIV12-AV0-61388971
http://linked.open...avai/predkladatel	Mikrobiologický ústav AV ČR, v.v.i.
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(AV0Z50200510)
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Šrůtková, Dagmar Kozáková, Hana Schwarzer, Martin Hudcovic, Tomáš Štěpánková, Renata Hrnčíř, Tomáš Tlaskalová-Hogenová, Helena
http://linked.open.../riv/druhVysledku	O - Ostatní výsledky nezařaditelné do žádného z výše uvedených druhů výsledku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Mikrobiologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	215547
http://linked.open...ai/riv/idVysledku	RIV/61388971:_____/11:00375208
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	germ-free mice; allergy (en)
http://linked.open.../riv/klicoveSlovo	allergy germ-free mice
http://linked.open...ontrolniKodProRIV	[6AC4D0F786CA]
http://linked.open...in/vavai/riv/obor	EC
http://linked.open...ichTvurcuVysledku	7 (xsd:int)
http://linked.open...cetTvurcuVysledku	12 (xsd:int)
http://linked.open...UplatneniVysledku	2011
http://linked.open...iv/tvurceVysledku	Tlaskalová-Hogenová, Helena Kozáková, Hana Schwarzer, Martin Šrůtková, Dagmar Hudcovic, Tomáš Daniel, C. Hrnčíř, Tomáš Pot, B. Repa, A. Schabussova, I. Wiedermann, U. Štěpánková, Renata
http://linked.open...n/vavai/riv/zamer	Microorganisms in Research and Biotechnology

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