About: Rapid changes in gene expression: DNA determinants of promoter regulation by the

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	In bacteria, rapid changes in gene expression can be achieved by affecting the activity of RNA polymerase with small molecule effectors during transcription initiation. An important small molecule effector is the initiating nucleoside triphosphate (iNTP). At some promoters, an increasing iNTP concentration stimulates promoter activity, while a decreasing concentration has the opposite effect. Ribosomal RNA (rRNA) promoters from Grampositive Bacillus subtilis are regulated by the concentration of their iNTP. Yet, the sequences of these promoters do not emulate the sequence characteristics of [iNTP]-regulated rRNA promoters of Gram-negative Escherichia coli. Here, we identified the 30-promoter region, corresponding to the transcription bubble, as key for B. subtilis rRNA promoter regulation via the concentration of the iNTP In bacteria, rapid changes in gene expression can be achieved by affecting the activity of RNA polymerase with small molecule effectors during transcription initiation. An important small molecule effector is the initiating nucleoside triphosphate (iNTP). At some promoters, an increasing iNTP concentration stimulates promoter activity, while a decreasing concentration has the opposite effect. Ribosomal RNA (rRNA) promoters from Grampositive Bacillus subtilis are regulated by the concentration of their iNTP. Yet, the sequences of these promoters do not emulate the sequence characteristics of [iNTP]-regulated rRNA promoters of Gram-negative Escherichia coli. Here, we identified the 30-promoter region, corresponding to the transcription bubble, as key for B. subtilis rRNA promoter regulation via the concentration of the iNTP (en)
Title	Rapid changes in gene expression: DNA determinants of promoter regulation by the Rapid changes in gene expression: DNA determinants of promoter regulation by the (en)
skos:prefLabel	Rapid changes in gene expression: DNA determinants of promoter regulation by the Rapid changes in gene expression: DNA determinants of promoter regulation by the (en)
skos:notation	RIV/61388971:_____/11:00360790!RIV12-AV0-61388971
http://linked.open...avai/predkladatel	Mikrobiologický ústav AV ČR, v.v.i.
http://linked.open...avai/riv/aktivita	P S Z
http://linked.open...avai/riv/aktivity	P(2B06065), S, Z(AV0Z50200510), Z(MSM0021620835)
http://linked.open...iv/cisloPeriodika	11
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Krásný, Libor Maderová, Zdeňka Šanderová, Hana Sojka, Luděk Kouba, Tomáš Jonák, Jiří
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Mikrobiologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	225703
http://linked.open...ai/riv/idVysledku	RIV/61388971:_____/11:00360790
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	RIBOSOMAL-RNA TRANSCRIPTION; ILV-LEU OPERON; CHAIN AMINO-ACIDS (en)
http://linked.open.../riv/klicoveSlovo	CHAIN AMINO-ACIDS ILV-LEU OPERON RIBOSOMAL-RNA TRANSCRIPTION
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[61AD40274D5A]
http://linked.open...i/riv/nazevZdroje	Nucleic Acids Research
http://linked.open...in/vavai/riv/obor	EE
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	New Generation of Antibacterial Agens
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	39
http://linked.open...iv/tvurceVysledku	Krásný, Libor Šanderová, Hana Barvík, I. Jonák, Jiří Kouba, Tomáš Maderová, Zdeňka Sojka, Luděk
http://linked.open...ain/vavai/riv/wos	000291755000013
http://linked.open...n/vavai/riv/zamer	Microorganisms in Research and Biotechnology Fyzika molekulárních, makromolekulárních a biologických systémů
issn	0305-1048
number of pages	14 (xsd:int)
http://bibframe.org/vocab/doi	10.1093/nar/gkr032
is http://linked.open...avai/riv/vysledek of	Rapid changes in gene expression: DNA determinants of promoter regulation by the Rapid changes in gene expression: DNA determinants of promoter regulation by the

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