About: Identification of Multiple Substrates of the StkP Ser/Thr Protein Kinase in Streptococcus pneumoniae

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About: Identification of Multiple Substrates of the StkP Ser/Thr Protein Kinase in Streptococcus pneumoniae Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The human pathogen Streptococcus pneumoniae encodes a single copy of a eukaryotic-like Ser/Thr protein kinase gene designated stkP. Previous studies demonstrated the pleiotropic role of the transmembrane protein kinase StkP in pneumococcal physiology. StkP regulates virulence, competence, and stress resistance and plays a role in the regulation of gene expression. In this study we identified three new substrates of StkP: the Mn-dependent inorganic pyrophosphatase PpaC, the hypothetical protein spr0334, and the cell division protein DivIVA. We showed that StkP activation and substrate recognition depend on the presence of a peptidoglycan-binding domain comprising four PASTA domain repeats. We found that StkP is regulated in a growth-dependent manner and likely senses intracellular peptidoglycan subunits present in the cell division septa The human pathogen Streptococcus pneumoniae encodes a single copy of a eukaryotic-like Ser/Thr protein kinase gene designated stkP. Previous studies demonstrated the pleiotropic role of the transmembrane protein kinase StkP in pneumococcal physiology. StkP regulates virulence, competence, and stress resistance and plays a role in the regulation of gene expression. In this study we identified three new substrates of StkP: the Mn-dependent inorganic pyrophosphatase PpaC, the hypothetical protein spr0334, and the cell division protein DivIVA. We showed that StkP activation and substrate recognition depend on the presence of a peptidoglycan-binding domain comprising four PASTA domain repeats. We found that StkP is regulated in a growth-dependent manner and likely senses intracellular peptidoglycan subunits present in the cell division septa (en)
Title	Identification of Multiple Substrates of the StkP Ser/Thr Protein Kinase in Streptococcus pneumoniae Identification of Multiple Substrates of the StkP Ser/Thr Protein Kinase in Streptococcus pneumoniae (en)
skos:prefLabel	Identification of Multiple Substrates of the StkP Ser/Thr Protein Kinase in Streptococcus pneumoniae Identification of Multiple Substrates of the StkP Ser/Thr Protein Kinase in Streptococcus pneumoniae (en)
skos:notation	RIV/61388971:_____/10:00348138!RIV11-GA0-61388971
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA204/08/0783), P(GP204/07/P082), P(IAA600200801), Z(AV0Z50200510)
http://linked.open...iv/cisloPeriodika	14
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Sasková, Lenka Branny, Pavel Weiser, Jaroslav Pompach, Petr Bezoušková, Silvia Nováková, Linda
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Mikrobiologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	262710
http://linked.open...ai/riv/idVysledku	RIV/61388971:_____/10:00348138
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	GROUP-B STREPTOCOCCUS; EUKARYOTIC-TYPE; SERINE/THREONINE KINASE (en)
http://linked.open.../riv/klicoveSlovo	SERINE/THREONINE KINASE EUKARYOTIC-TYPE GROUP-B STREPTOCOCCUS
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[BCAA46733001]
http://linked.open...i/riv/nazevZdroje	Journal of Bacteriology
http://linked.open...in/vavai/riv/obor	EE
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Relationship between the virulence of pathogenic bacteria and the presence of eukaryotic-type Ser/Thr protein kinases Analysis of substrates of Ser/Thr protein kinase StkP in Streptococcus pneumoniae and impact of phosphorylation on their function Bacterial signalling systems and regulation of the cell wall biosynthesis
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	192
http://linked.open...iv/tvurceVysledku	Branny, Pavel Pompach, Petr Weiser, Jaroslav Bezoušková, Silvia Nováková, Linda Přenosilová, Lenka
http://linked.open...ain/vavai/riv/wos	000279183300008
http://linked.open...n/vavai/riv/zamer	Microorganisms in Research and Biotechnology
issn	0021-9193
number of pages	10 (xsd:int)
is http://linked.open...avai/riv/vysledek of	Identification of Multiple Substrates of the StkP Ser/Thr Protein Kinase in Streptococcus pneumoniae Identification of Multiple Substrates of the StkP Ser/Thr Protein Kinase in Streptococcus pneumoniae Identification of Multiple Substrates of the StkP Ser/Thr Protein Kinase in Streptococcus pneumoniae

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