About: Enzymatic preparation of acylated derivatives of silybin in organic and ionic liquid media and evaluation of their antitumor proliferative aktivity     Goto   Sponge   NotDistinct   Permalink

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  • Biocatalytic preparation of acylated derivatives of silybin using several acyl donors (free fatty acids or their esters), catalyzed by immobilized Candida antarctica lipase B, was performed in various organic solvents as well as in imidazolium-based ionic liquids containing either BF-4 or PF-6 anions. Total conversion of silybin was achieved in acetone using short-chain acyl donors (vinyl butanoate) at a 10:1 molar ratio of acyl donor to silybin. The enzymatic process in ionic liquids depended strongly on the alkyl chain length of the cation as well the anion used. Higher conversion yields (up to 75.8 percent) and reaction rates (up to 0.31 mmol h-1 g-1 biocatalyst) were obtained in the BF-4 as compared with PF-6 - containing ionic liquids
  • Biocatalytic preparation of acylated derivatives of silybin using several acyl donors (free fatty acids or their esters), catalyzed by immobilized Candida antarctica lipase B, was performed in various organic solvents as well as in imidazolium-based ionic liquids containing either BF-4 or PF-6 anions. Total conversion of silybin was achieved in acetone using short-chain acyl donors (vinyl butanoate) at a 10:1 molar ratio of acyl donor to silybin. The enzymatic process in ionic liquids depended strongly on the alkyl chain length of the cation as well the anion used. Higher conversion yields (up to 75.8 percent) and reaction rates (up to 0.31 mmol h-1 g-1 biocatalyst) were obtained in the BF-4 as compared with PF-6 - containing ionic liquids (en)
Title
  • Enzymatic preparation of acylated derivatives of silybin in organic and ionic liquid media and evaluation of their antitumor proliferative aktivity
  • Enzymatic preparation of acylated derivatives of silybin in organic and ionic liquid media and evaluation of their antitumor proliferative aktivity (en)
skos:prefLabel
  • Enzymatic preparation of acylated derivatives of silybin in organic and ionic liquid media and evaluation of their antitumor proliferative aktivity
  • Enzymatic preparation of acylated derivatives of silybin in organic and ionic liquid media and evaluation of their antitumor proliferative aktivity (en)
skos:notation
  • RIV/61388971:_____/09:00328344!RIV10-MSM-61388971
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(ME 922), Z(AV0Z50200510)
http://linked.open...iv/cisloPeriodika
  • 3
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 313394
http://linked.open...ai/riv/idVysledku
  • RIV/61388971:_____/09:00328344
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • silybin; lipase; ionic liquids (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV
  • [46AF4C089F15]
http://linked.open...i/riv/nazevZdroje
  • Biocatalysis and Biotransformation
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 27
http://linked.open...iv/tvurceVysledku
  • Křen, Vladimír
  • Purchartová, Kateřina
  • Stamatis, H.
  • Theodosiou, E.
  • Katsoura, M. H.
  • Kolisis, F. N.
  • Loutrari, H.
http://linked.open...ain/vavai/riv/wos
  • 000268032500001
http://linked.open...n/vavai/riv/zamer
issn
  • 1024-2422
number of pages
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