About: Mammalian complex I: A regulable and vulnerable pacemaker in mitochlondrial respiratory function

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About: Mammalian complex I: A regulable and vulnerable pacemaker in mitochlondrial respiratory function Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	In this paper the regulatory features of complex I of mammalian and human mitochondria are reviewed. In a variety of mitotic cell-line cultures, activation in vivo of the cAMP cascade, or direct addition of cAMP, promotes the NADH–ubiquinone oxidoreductase activity of complex I and lower the cellular level of ROS. These effects of cAMP are found to be associated with PKA-mediated serine phosphorylation in the conserved C-terminus of the subunit of complex I encoded by the nuclear gene NDUFS4. PKA mediated phosphorylation of this Ser in the C-terminus of the protein promotes its mitochondrial import and maturation. Massspectrometry analysis of the phosphorylation pattern of complex I subunits is also reviewed In this paper the regulatory features of complex I of mammalian and human mitochondria are reviewed. In a variety of mitotic cell-line cultures, activation in vivo of the cAMP cascade, or direct addition of cAMP, promotes the NADH–ubiquinone oxidoreductase activity of complex I and lower the cellular level of ROS. These effects of cAMP are found to be associated with PKA-mediated serine phosphorylation in the conserved C-terminus of the subunit of complex I encoded by the nuclear gene NDUFS4. PKA mediated phosphorylation of this Ser in the C-terminus of the protein promotes its mitochondrial import and maturation. Massspectrometry analysis of the phosphorylation pattern of complex I subunits is also reviewed (en) cAMP kaskáda ne přímo přidání cAMP zvyšuje aktivitu NADH-ubiquinone oxidoreduktázy v komplexu I a snižují aktivitu ROS. Tyto efekty jsou spojeny s PKA podporovanou fosforylaci na serinu v konzervované C oblasti. Práce posuzuje MS analýzy fosforylačních profilů komplexu I (cs)
Title	Mammalian complex I: A regulable and vulnerable pacemaker in mitochlondrial respiratory function Mammalian complex I: A regulable and vulnerable pacemaker in mitochlondrial respiratory function (en) Savčí komplex I: regulovatelný a přístupný indikátor mitocondriální respirační funkce (cs)
skos:prefLabel	Mammalian complex I: A regulable and vulnerable pacemaker in mitochlondrial respiratory function Mammalian complex I: A regulable and vulnerable pacemaker in mitochlondrial respiratory function (en) Savčí komplex I: regulovatelný a přístupný indikátor mitocondriální respirační funkce (cs)
skos:notation	RIV/61388971:_____/08:00320792!RIV09-AV0-61388971
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(AV0Z50200510)
http://linked.open...iv/cisloPeriodika	7-8
http://linked.open...vai/riv/dodaniDat	2009
http://linked.open...aciTvurceVysledku	Techniková, Zuzana
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Mikrobiologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	377563
http://linked.open...ai/riv/idVysledku	RIV/61388971:_____/08:00320792
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	complex I; proton pump; mitochondrial import (en)
http://linked.open.../riv/klicoveSlovo	mitochondrial import proton pump complex I
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[01F1C4E1E554]
http://linked.open...i/riv/nazevZdroje	Biochimica Et Biophysica Acta-Bioenergetics
http://linked.open...in/vavai/riv/obor	EE
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	11 (xsd:int)
http://linked.open...UplatneniVysledku	2008
http://linked.open...v/svazekPeriodika	1777
http://linked.open...iv/tvurceVysledku	Dobrová, Zuzana De Rasmo, D. Palmisano, G. Panelli, D. Papa, F. Papa, S. Santeramo, A. Sardanelli, A. M. Scacco, S. Scaringi, R. Signorile, A.
http://linked.open...ain/vavai/riv/wos	000257696400023
http://linked.open...n/vavai/riv/zamer	Microorganisms in Research and Biotechnology
issn	0005-2728
number of pages	10 (xsd:int)
is http://linked.open...avai/riv/vysledek of	Mammalian complex I: A regulable and vulnerable pacemaker in mitochlondrial respiratory function Mammalian complex I: A regulable and vulnerable pacemaker in mitochlondrial respiratory function Mammalian complex I: A regulable and vulnerable pacemaker in mitochlondrial respiratory function Mammalian complex I: A regulable and vulnerable pacemaker in mitochlondrial respiratory function

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