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| Description
| - Sterile immunity against malaria can be achieved by the induction of IFNγ-producing CD8+ T cells that target infected hepatocytes presenting epitopes of the circumsporozoite protein (CSP). In the present study we evaluate the protective efficacy of a heterologous prime/boost immunization protocol based on the delivery of the CD8+ epitope of Plasmodium berghei CSP into the MHC class I presentation pathway, by either a type III secretion system of live recombinant Salmonella and/or by direct translocation of a recombinant Bordetella adenylate cyclase toxoid fusion (ACT-CSP) into the cytosol of professional antigen presenting cells (APCs). A single intraperitoneal application of the recombinant ACT-CSP toxoid, as well as a single oral immunization with the Salmonella vaccine, induced a specific CD8+ T cell response, which however conferred only a partial protection on mice against a subsequent sporozoite challenge
- Sterile immunity against malaria can be achieved by the induction of IFNγ-producing CD8+ T cells that target infected hepatocytes presenting epitopes of the circumsporozoite protein (CSP). In the present study we evaluate the protective efficacy of a heterologous prime/boost immunization protocol based on the delivery of the CD8+ epitope of Plasmodium berghei CSP into the MHC class I presentation pathway, by either a type III secretion system of live recombinant Salmonella and/or by direct translocation of a recombinant Bordetella adenylate cyclase toxoid fusion (ACT-CSP) into the cytosol of professional antigen presenting cells (APCs). A single intraperitoneal application of the recombinant ACT-CSP toxoid, as well as a single oral immunization with the Salmonella vaccine, induced a specific CD8+ T cell response, which however conferred only a partial protection on mice against a subsequent sporozoite challenge (en)
- Indukce specifické CTL buněčné odpovědi proti malarickému antigenu CSP zajišťuje ochranou imunitu proti malárii. V této práci jsme analyzovali roli prime/boost imunizačního protokolu v indukci CSP-zprostředkované ochranné imunity. Doprava CD8+ epitopu CSP do MHC-I dráhy antigenní prezentace pomocí rekombinantního ACT (ACT-CSP) anebo pomocí sekrečního systému typu III živé rekombinantní Salmonelly indukovala pouze částečnou ochranou imunitu. Avšak, použití prime/boost imunizačního protokolu vedlo k výraznému zvýšení CSP-specifických T buněk a kompletní protekci ve všech imunizovaných myších (cs)
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| Title
| - Complete protection against P. berghei malaria upon heterologous prime/boost immunization against circumsporozoite protein employing Salmonella type III secretion system and Bordetella adenylate cyclase toxoid
- Prime/boost imunizační protokol antigenu CSP využívající sekreční systém typu III živé rekombinantní Salmonelly a rekombinantního ACT zajišťuje ochranou imunitu proti malarické infekci (cs)
- Complete protection against P. berghei malaria upon heterologous prime/boost immunization against circumsporozoite protein employing Salmonella type III secretion system and Bordetella adenylate cyclase toxoid (en)
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| skos:prefLabel
| - Complete protection against P. berghei malaria upon heterologous prime/boost immunization against circumsporozoite protein employing Salmonella type III secretion system and Bordetella adenylate cyclase toxoid
- Prime/boost imunizační protokol antigenu CSP využívající sekreční systém typu III živé rekombinantní Salmonelly a rekombinantního ACT zajišťuje ochranou imunitu proti malarické infekci (cs)
- Complete protection against P. berghei malaria upon heterologous prime/boost immunization against circumsporozoite protein employing Salmonella type III secretion system and Bordetella adenylate cyclase toxoid (en)
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| skos:notation
| - RIV/61388971:_____/08:00315788!RIV09-AV0-61388971
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
| - P(2B06161), Z(AV0Z50200510)
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/61388971:_____/08:00315788
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - circumsporozoite protein; vaccine; salmonella (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
| - GB - Spojené království Velké Británie a Severního Irska
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...vavai/riv/projekt
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Kamanová, Jana
- Šebo, Peter
- Fleischer, B.
- Heussler, V.
- Jacobs, T.
- Tartz, S.
- Sturm, A.
- Rüssmann, H.
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| http://linked.open...ain/vavai/riv/wos
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| http://linked.open...n/vavai/riv/zamer
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| issn
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| number of pages
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| is http://linked.open...avai/riv/vysledek
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