About: Susceptibility to nasal and oral tolerance induction to the major birch pollen allergen Bet v 1 is not dependent on the presence of the microflora

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About: Susceptibility to nasal and oral tolerance induction to the major birch pollen allergen Bet v 1 is not dependent on the presence of the microflora Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Bezmikrobní a konvenční BALB/c myši byly před senzitizací intranasálně a nebo intragastricky předléčeny hlavní složkou březového pylu Bet v 1. Obě skupiny myši vykazovaly po alergické senzitizaci stejné nasměrování Th2 imunitní odpovědi. Nastolená orální, stejně jako intranasální slizniční tolerance, vedla k potlačení základní alergické protilátkové odpovědi (IgG1, IgE, IgA) a podobně byla změněna i produkce cytokinů (IL-5, IFN-gama) uvolněných po kultivaci slezinných lymfocytů a to jak u bezmikrobních, tak i u konvenčních myší. Z těchto výsledků vyplývá, že nepřítomnost střevní mikroflóry neovlivnila ani Th2 alergickou odpověď po senzitizaci alergenem, ani navození slizniční tolerance k tomu vzdušnému alergenu Bet v 1 (cs) Germ-free or conventional BALB/c mice were intranasally or intragastrically pre-treated with the major birch pollen allergen Bet v 1 prior to sensitization with this allergen. Both germ-free and conventional mice displayed comparable Th2 biased immune responses after allergic sensitization. Oral as well as intranasal tolerization led to suppression of allergen-specific serum antibodies (IgG1, IgE, IgA) as well as cytokine production by splenocytes (IL-5, IFN-gamma) in both germ-free and conventional animals. We conclude that the absence of the microflora does not influence the ability to mount Th2 responses nor to establish tolerance towards the aeroallergen Bet v 1 Germ-free or conventional BALB/c mice were intranasally or intragastrically pre-treated with the major birch pollen allergen Bet v 1 prior to sensitization with this allergen. Both germ-free and conventional mice displayed comparable Th2 biased immune responses after allergic sensitization. Oral as well as intranasal tolerization led to suppression of allergen-specific serum antibodies (IgG1, IgE, IgA) as well as cytokine production by splenocytes (IL-5, IFN-gamma) in both germ-free and conventional animals. We conclude that the absence of the microflora does not influence the ability to mount Th2 responses nor to establish tolerance towards the aeroallergen Bet v 1 (en)
Title	Susceptibility to nasal and oral tolerance induction to the major birch pollen allergen Bet v 1 is not dependent on the presence of the microflora Vnímavost k navození nasální a orální tolerance k hlavní složce březového pylu Bet v 1 není závislá na přítomnosti mikroflóry (cs) Susceptibility to nasal and oral tolerance induction to the major birch pollen allergen Bet v 1 is not dependent on the presence of the microflora (en)
skos:prefLabel	Susceptibility to nasal and oral tolerance induction to the major birch pollen allergen Bet v 1 is not dependent on the presence of the microflora Vnímavost k navození nasální a orální tolerance k hlavní složce březového pylu Bet v 1 není závislá na přítomnosti mikroflóry (cs) Susceptibility to nasal and oral tolerance induction to the major birch pollen allergen Bet v 1 is not dependent on the presence of the microflora (en)
skos:notation	RIV/61388971:_____/08:00313088!RIV09-AV0-61388971
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1QS500200572), P(GA303/05/2249), P(GA303/06/0974), Z(AV0Z50200510)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2009
http://linked.open...aciTvurceVysledku	Kozáková, Hana Hudcovic, Tomáš Štěpánková, Renata Hrnčíř, Tomáš Tlaskalová-Hogenová, Helena
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Mikrobiologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	398472
http://linked.open...ai/riv/idVysledku	RIV/61388971:_____/08:00313088
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	gnotobiotics; mucosal immunity; allergy (en)
http://linked.open.../riv/klicoveSlovo	gnotobiotics allergy mucosal immunity
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[7D928B676383]
http://linked.open...i/riv/nazevZdroje	Immunology Letters
http://linked.open...in/vavai/riv/obor	EC
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...vavai/riv/projekt	Development of new tools for diagnosis and therapy of CrohnŮs disease and ulcerative colitis Development of immune responses to birch pollen allergen after colonization of mucosal surfaces with recombinant lactobacilli expressing this allergen Interaction of commensal and probiotic bacteria with gut mucosa studied in gnotobiotic models
http://linked.open...UplatneniVysledku	2008
http://linked.open...v/svazekPeriodika	117
http://linked.open...iv/tvurceVysledku	Kozáková, Hana Hudcovic, Tomáš Hrnčíř, Tomáš Pollak, A. Repa, A. Tlaskalová, Helena Wiedermann, U. Štěpánková, Renata
http://linked.open...ain/vavai/riv/wos	000255183400007
http://linked.open...n/vavai/riv/zamer	Microorganisms in Research and Biotechnology
issn	0165-2478
number of pages	7 (xsd:int)
is http://linked.open...avai/riv/vysledek of	Susceptibility to nasal and oral tolerance induction to the major birch pollen allergen Bet v 1 is not dependent on the presence of the microflora Susceptibility to nasal and oral tolerance induction to the major birch pollen allergen Bet v 1 is not dependent on the presence of the microflora Susceptibility to nasal and oral tolerance induction to the major birch pollen allergen Bet v 1 is not dependent on the presence of the microflora Susceptibility to nasal and oral tolerance induction to the major birch pollen allergen Bet v 1 is not dependent on the presence of the microflora

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