About: The Fission Yeast Ortholog of eIF3a Subunit Is Not Functional in Saccharomyces cerevisiae

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Největší podjednotka translačního iniciačního faktoru 3 eIF3a je vývojově velmi konzervativním proteinem. V práci popisujeme izolaci sekvence kódující eIF3a v S.pombe (SpeIF3a) a testování funkce SpeIF3a v pučící kvasince S.cerevisiae. Zjistili jsme, že ani nadprodukce tohoto ortologu neovlivňuje tvorbu endogenního eIF3 komplexu, nicméně SpeIF3a je vázán na ribosomy pevněji než endogenní eIF3a. Jeho nadprodukce způsobuje výrazné defekty v morfologii buněk (cs) The largest subunit of the translation initiation factor 3 eIF3a is an evolutionary conserved protein. Here we describe isolation of the eIF3a from Schizosaccharomyces pombe (SpeIF3a) and subsequent testing of its function in budding yeast Saccharomyces cerevisiae. We found that formation of the endogenous eIF3 complex was not affected by the overproduction of SpeIF3a in S. cerevisiae but SpeIF3a was more tightly bound to S. cerevisiae ribosomes than the endogenous eIF3a. Its expression resulted in alteration of cell morphology The largest subunit of the translation initiation factor 3 eIF3a is an evolutionary conserved protein. Here we describe isolation of the eIF3a from Schizosaccharomyces pombe (SpeIF3a) and subsequent testing of its function in budding yeast Saccharomyces cerevisiae. We found that formation of the endogenous eIF3 complex was not affected by the overproduction of SpeIF3a in S. cerevisiae but SpeIF3a was more tightly bound to S. cerevisiae ribosomes than the endogenous eIF3a. Its expression resulted in alteration of cell morphology (en)
Title	The Fission Yeast Ortholog of eIF3a Subunit Is Not Functional in Saccharomyces cerevisiae Ortholog eIF3a podjednotky kvasinky Schizosaccharomyces pombe není funkční v Saccharomyces cerevisiae (cs) The Fission Yeast Ortholog of eIF3a Subunit Is Not Functional in Saccharomyces cerevisiae (en)
skos:prefLabel	The Fission Yeast Ortholog of eIF3a Subunit Is Not Functional in Saccharomyces cerevisiae Ortholog eIF3a podjednotky kvasinky Schizosaccharomyces pombe není funkční v Saccharomyces cerevisiae (cs) The Fission Yeast Ortholog of eIF3a Subunit Is Not Functional in Saccharomyces cerevisiae (en)
skos:notation	RIV/61388971:_____/07:00084799!RIV08-AV0-61388971
http://linked.open.../vavai/riv/strany	555;564
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA204/02/1424), P(GA204/05/0838), Z(AV0Z50200510)
http://linked.open...iv/cisloPeriodika	6
http://linked.open...vai/riv/dodaniDat	2008
http://linked.open...aciTvurceVysledku	Raková, Radka Koubek, Zdeněk Malínská, Kateřina Malcová, Ivana Hašek, Jiří
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Mikrobiologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	422146
http://linked.open...ai/riv/idVysledku	RIV/61388971:_____/07:00084799
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	saccharomyces cerevisiae; yeast; protein (en)
http://linked.open.../riv/klicoveSlovo	protein yeast saccharomyces cerevisiae
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[B9A25199B686]
http://linked.open...i/riv/nazevZdroje	Folia Microbiologica
http://linked.open...in/vavai/riv/obor	EE
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Role of cytoskeletal interactions of the translation initiation factor eIF3 in yeast morphogenesis Role of eIF3a/Rpg1p in reassembly of microtubules and stress response in yeast
http://linked.open...UplatneniVysledku	2007
http://linked.open...v/svazekPeriodika	51
http://linked.open...iv/tvurceVysledku	Malínská, Kateřina Hašek, Jiří Malcová-Janatová, Ivana Koubek, Zdeněk Raková, Radka
http://linked.open...n/vavai/riv/zamer	Microorganisms in Research and Biotechnology
issn	0015-5632
number of pages	10 (xsd:int)
is http://linked.open...avai/riv/vysledek of	The Fission Yeast Ortholog of eIF3a Subunit Is Not Functional in Saccharomyces cerevisiae The Fission Yeast Ortholog of eIF3a Subunit Is Not Functional in Saccharomyces cerevisiae The Fission Yeast Ortholog of eIF3a Subunit Is Not Functional in Saccharomyces cerevisiae

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