About: Structural model for the multisubunit Type IC restriction-modification DNA methyltransferase M.EcoR124I in complex with DNA

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About: Structural model for the multisubunit Type IC restriction-modification DNA methyltransferase M.EcoR124I in complex with DNA Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Nedávné zveřejnění krystalových struktur DNA vazebných podjednotek (HsdS) dosud funkčně necharakterizovaných restrikčně-modifikačních (R-M) enzymů MjaXIP a MgeORF438 poskytlo vhodný strukturní templát pro analýzu extenzivněji charakterizovaných členů této zajímavé skupiny molekulárních motorů. V této práci prezentujeme strukturní model DNA methyltranferázy Typu IC M.EcoR124I sestávající z podjednotky HsdS, dvou podjednotek HsdM, kofaktoru AdoMet a substrátové molekuly DNA. Tento strukturní model spolu s lokalizací mutaních zbytků poskytuje lepší základ pro studium interakcí protein-protein a protein- DNA R-M systémů Typu I (cs) Recent publication of crystal structures for the putative DNA-binding subunits (HsdS) of the functionally uncharacterised Type I Restriction-Modification (R-M) enzymes MjaXIP and MgeORF438 have provided a convenient structural template for analysis of the more extensively characterised members of this interesting family of multisubunit molecular motors. Here, we present a structural model of the Type IC M.EcoR124I DNA methyltransferase (MTase), comprising the HsdS subunit, two HsdM subunits, the cofactor AdoMet and the substrate DNA molecule. The model structure, together with location of the mutant residues, provides a better background on which to study protein-protein and protein-DNA interactions in Type I R-M systems Recent publication of crystal structures for the putative DNA-binding subunits (HsdS) of the functionally uncharacterised Type I Restriction-Modification (R-M) enzymes MjaXIP and MgeORF438 have provided a convenient structural template for analysis of the more extensively characterised members of this interesting family of multisubunit molecular motors. Here, we present a structural model of the Type IC M.EcoR124I DNA methyltransferase (MTase), comprising the HsdS subunit, two HsdM subunits, the cofactor AdoMet and the substrate DNA molecule. The model structure, together with location of the mutant residues, provides a better background on which to study protein-protein and protein-DNA interactions in Type I R-M systems (en)
Title	Structural model for the multisubunit Type IC restriction-modification DNA methyltransferase M.EcoR124I in complex with DNA Strukturní model multipodjednotkové restrikčně-modifikační DNA methyltransferázy Typu IC M.EcoR124I v komplexu s DNA (cs) Structural model for the multisubunit Type IC restriction-modification DNA methyltransferase M.EcoR124I in complex with DNA (en)
skos:prefLabel	Structural model for the multisubunit Type IC restriction-modification DNA methyltransferase M.EcoR124I in complex with DNA Strukturní model multipodjednotkové restrikčně-modifikační DNA methyltransferázy Typu IC M.EcoR124I v komplexu s DNA (cs) Structural model for the multisubunit Type IC restriction-modification DNA methyltransferase M.EcoR124I in complex with DNA (en)
skos:notation	RIV/61388971:_____/06:00044215!RIV07-GA0-61388971
http://linked.open.../vavai/riv/strany	1992;2005
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA204/03/1011), Z(AV0Z50200510)
http://linked.open...iv/cisloPeriodika	7
http://linked.open...vai/riv/dodaniDat	2007
http://linked.open...aciTvurceVysledku	Weiserová, Marie Šišáková, Eva Vejsadová, Štěpánka
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Mikrobiologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	501930
http://linked.open...ai/riv/idVysledku	RIV/61388971:_____/06:00044215
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	hsds; molecular motors; crystal structures (en)
http://linked.open.../riv/klicoveSlovo	crystal structures hsds molecular motors
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[8818F43A0F5A]
http://linked.open...i/riv/nazevZdroje	Nucleic Acids Research
http://linked.open...in/vavai/riv/obor	EE
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...vavai/riv/projekt	Uncoupling of DNA restriction and DNA translocation functions of EcoR124I restriction-modification enzyme - a potential melecular motor
http://linked.open...UplatneniVysledku	2006
http://linked.open...v/svazekPeriodika	34
http://linked.open...iv/tvurceVysledku	Weiserová, Marie Šišáková, Eva Vejsadová, Štěpánka Firman, K. Blundell, A. Bujnicki, J. M. Feder, M. Obarska, A.
http://linked.open...n/vavai/riv/zamer	Microorganisms in Research and Biotechnology
issn	0305-1048
number of pages	14 (xsd:int)
is http://linked.open...avai/riv/vysledek of	Structural model for the multisubunit Type IC restriction-modification DNA methyltransferase M.EcoR124I in complex with DNA Structural model for the multisubunit Type IC restriction-modification DNA methyltransferase M.EcoR124I in complex with DNA

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