About: HlyA knock out yields a safer Escherichia coli A0 34/86 variant with unaffected colonization capacity in piglets

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Escherichia coli A0 34/86 (O83:K24:H31) has been successfully used for prophylactic and therapeutic intestinal colonization of premature and newborn infants, with the aim of preventing nosocomial infections. Although E. coli A0 34/86 was described as a nonpathogenic commensal, partial sequencing revealed that its genome harbours gene clusters highly homologous to virulence determinants of different types of E. coli, including closely linked genes of the a-haemolysin operon (hlyCABD) and for the cytotoxic necrotizing factor (cnf1). A haemolysin-deficient mutant (hlyA) of E. coli A0 34/86 was generated and its colonization capacity was determined. The results show that a single dose of the A0 34/86 wild-type or hlyA strains resulted in efficient intestinal colonization of newborn conventional piglets, and that this was still considerable after several weeks Escherichia coli A0 34/86 (O83:K24:H31) has been successfully used for prophylactic and therapeutic intestinal colonization of premature and newborn infants, with the aim of preventing nosocomial infections. Although E. coli A0 34/86 was described as a nonpathogenic commensal, partial sequencing revealed that its genome harbours gene clusters highly homologous to virulence determinants of different types of E. coli, including closely linked genes of the a-haemolysin operon (hlyCABD) and for the cytotoxic necrotizing factor (cnf1). A haemolysin-deficient mutant (hlyA) of E. coli A0 34/86 was generated and its colonization capacity was determined. The results show that a single dose of the A0 34/86 wild-type or hlyA strains resulted in efficient intestinal colonization of newborn conventional piglets, and that this was still considerable after several weeks (en) Kmen Escherichia coli A0 34/86 (O83:K24:H31) je úspěšně používán pro preventivní kolonizaci novorozenců. V této práci ukazujeme, že jeho bezpečnost lze ještě vylepšit odstraněním genu pro hemolyzín, což neovlivní kolonizační schopnosti kmene v prasečím experimentálním modelu (cs)
Title	HlyA knock out yields a safer Escherichia coli A0 34/86 variant with unaffected colonization capacity in piglets Vyřazení HlyA vede k bezpečnější variantě kmene Escherichia coli A0 34/86 s nezměněnými kolonizačními schopnostmi (cs) HlyA knock out yields a safer Escherichia coli A0 34/86 variant with unaffected colonization capacity in piglets (en)
skos:prefLabel	HlyA knock out yields a safer Escherichia coli A0 34/86 variant with unaffected colonization capacity in piglets Vyřazení HlyA vede k bezpečnější variantě kmene Escherichia coli A0 34/86 s nezměněnými kolonizačními schopnostmi (cs) HlyA knock out yields a safer Escherichia coli A0 34/86 variant with unaffected colonization capacity in piglets (en)
skos:notation	RIV/61388971:_____/06:00043244!RIV07-GA0-61388971
http://linked.open.../vavai/riv/strany	257;266
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA523/03/0186), Z(AV0Z50200510)
http://linked.open...iv/cisloPeriodika	-
http://linked.open...vai/riv/dodaniDat	2007
http://linked.open...aciTvurceVysledku	Felsberg, Jürgen Šebo, Peter Holubová, Jana Sheshko, Valeria
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Mikrobiologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	477891
http://linked.open...ai/riv/idVysledku	RIV/61388971:_____/06:00043244
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	escherichia coli; haemolysin; colonization (en)
http://linked.open.../riv/klicoveSlovo	escherichia coli colonization haemolysin
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[74EA50282A6F]
http://linked.open...i/riv/nazevZdroje	FEMS Immunology and Medical Microbiology
http://linked.open...in/vavai/riv/obor	EE
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	10 (xsd:int)
http://linked.open...vavai/riv/projekt	Recombinant E. coli O83 as a live vector for mucosal vaccines
http://linked.open...UplatneniVysledku	2006
http://linked.open...v/svazekPeriodika	48
http://linked.open...iv/tvurceVysledku	Felsberg, Jürgen Šebo, Peter Faldyna, M. Alexa, P. Šinkora, J. Hejnová, Jana Bomba, A. Řeháková, Z. Sheshko, Valeria Němcová, R.
http://linked.open...n/vavai/riv/zamer	Microorganisms in Research and Biotechnology
issn	0928-8244
number of pages	12 (xsd:int)
is http://linked.open...avai/riv/vysledek of	HlyA knock out yields a safer Escherichia coli A0 34/86 variant with unaffected colonization capacity in piglets HlyA knock out yields a safer Escherichia coli A0 34/86 variant with unaffected colonization capacity in piglets

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