About: Transmission of Mycobacterium tuberculosis Undetected by Tuberculin Skin Testing

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Rationale: The development of tuberculin skin test (TST) positivity following infection by Mycobacterium tuberculosis is not invariable and may depend on bacillary as well as host factors. Objectives: First, to compare the diagnostic performance of the TST and a form of in vitro IFN-gamma release assay (IFNGRA) in the circumstances of a contact investigation prompted by an unusually severe index case of infectious pulmonary tuberculosis. Second, to investigate the ability of the strain of M. tuberculosis responsible to induce cytokine secretion from monocytes in vitro. Methods: A routine TST-based tuberculosis-contact screening procedure supplemented by the use of an %22in house%22 IFNGRA that assays the T-cell response to the M. tuberculosis-specific antigens ESAT-6, CFP-10 (presented as a fusion protein within the inactivated adenylate cyclase of Bordetella pertussis), and purified protein derivative of M. tuberculosis Rationale: The development of tuberculin skin test (TST) positivity following infection by Mycobacterium tuberculosis is not invariable and may depend on bacillary as well as host factors. Objectives: First, to compare the diagnostic performance of the TST and a form of in vitro IFN-gamma release assay (IFNGRA) in the circumstances of a contact investigation prompted by an unusually severe index case of infectious pulmonary tuberculosis. Second, to investigate the ability of the strain of M. tuberculosis responsible to induce cytokine secretion from monocytes in vitro. Methods: A routine TST-based tuberculosis-contact screening procedure supplemented by the use of an %22in house%22 IFNGRA that assays the T-cell response to the M. tuberculosis-specific antigens ESAT-6, CFP-10 (presented as a fusion protein within the inactivated adenylate cyclase of Bordetella pertussis), and purified protein derivative of M. tuberculosis (en) Práce ukazuje, že tuberkulinový kožní test, tak jak byl používán v UK (Heaf test) není spolehlivý a nedetekuje infekce atypickými kmeny Mycobacterium tuberculosis. V této práci popisujeme použití nově vyvinutého testu založeného na použití detekce in vitro uvolněného IFNg (cs)
Title	Transmission of Mycobacterium tuberculosis Undetected by Tuberculin Skin Testing Přenos Mycobacterium tuberculosis nedetekovaný kožním tuberkulinovým testem (cs) Transmission of Mycobacterium tuberculosis Undetected by Tuberculin Skin Testing (en)
skos:prefLabel	Transmission of Mycobacterium tuberculosis Undetected by Tuberculin Skin Testing Přenos Mycobacterium tuberculosis nedetekovaný kožním tuberkulinovým testem (cs) Transmission of Mycobacterium tuberculosis Undetected by Tuberculin Skin Testing (en)
skos:notation	RIV/61388971:_____/06:00039366!RIV07-AV0-61388971
http://linked.open.../vavai/riv/strany	1038;1042
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(IAA5020406), Z(AV0Z50200510)
http://linked.open...iv/cisloPeriodika	-
http://linked.open...vai/riv/dodaniDat	2007
http://linked.open...aciTvurceVysledku	Šimšová, Marcela Šebo, Peter
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Mikrobiologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	504247
http://linked.open...ai/riv/idVysledku	RIV/61388971:_____/06:00039366
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	adenylate cyclase; diagnostic tests and procedures; mycobacterium tuberculosis (en)
http://linked.open.../riv/klicoveSlovo	mycobacterium tuberculosis adenylate cyclase diagnostic tests and procedures
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[084DAC48282E]
http://linked.open...i/riv/nazevZdroje	American Journal of Respiratory and Critical Care Medicine
http://linked.open...in/vavai/riv/obor	EE
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	10 (xsd:int)
http://linked.open...vavai/riv/projekt	Mechanisms of membrane interaction and cytotoxic activity of adenylate cyclase
http://linked.open...UplatneniVysledku	2006
http://linked.open...v/svazekPeriodika	173
http://linked.open...iv/tvurceVysledku	Šebo, Peter Šimšová, Marcela Wilkinson, K. A. Wilkinson, R. J. Brown, J. R. Levin, M. Anderson, S. T. Newton, S. M. Nicol, M. P. Williams, A. J.
http://linked.open...n/vavai/riv/zamer	Microorganisms in Research and Biotechnology
issn	1073-449X
number of pages	5 (xsd:int)
is http://linked.open...avai/riv/vysledek of	Transmission of Mycobacterium tuberculosis Undetected by Tuberculin Skin Testing Transmission of Mycobacterium tuberculosis Undetected by Tuberculin Skin Testing

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