About: The Crystal Structure of Annexin A8 is Similar to that of Annexin A3     Goto   Sponge   NotDistinct   Permalink

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Description
  • Annexin A8 is a relatively infrequent and poorly studied member of this large family of calcium-binding and membrane-binding proteins. It is, however, associated with a specific disease, acute promyelocytic leukemia. We have solved its three-dimensional structure, which includes a moderately long and intact N terminus. The structure is closest to that of annexin A3 and highlights several important regions of inherent flexibility in the annexin molecule. The N terminus resembles that of annexin A3, as it lies along the concave surface of the molecule and inserts partially into the hydrophilic channel in its centre. Since both annexins A3 and A8 are expressed in promyelocytic cells during their differentiation, the similarity in their structures might suggest a functional relationship
  • Annexin A8 is a relatively infrequent and poorly studied member of this large family of calcium-binding and membrane-binding proteins. It is, however, associated with a specific disease, acute promyelocytic leukemia. We have solved its three-dimensional structure, which includes a moderately long and intact N terminus. The structure is closest to that of annexin A3 and highlights several important regions of inherent flexibility in the annexin molecule. The N terminus resembles that of annexin A3, as it lies along the concave surface of the molecule and inserts partially into the hydrophilic channel in its centre. Since both annexins A3 and A8 are expressed in promyelocytic cells during their differentiation, the similarity in their structures might suggest a functional relationship (en)
  • Annexin A8 je vzácný a málo studovaný člen rozsáhlé rodiny membránových proteinů schopných vázat vápník. Tento protein bývá asociovaný s některými chorobami jako je akutní promyelocytická leukemie. Rozřešili jsme trojrozměrnou strukturu tohoto proteinu, která se podobá struktuře annexinu A3. Podobnost obou struktur upozorňuje na funkční příbuznost obou proteinů (cs)
Title
  • The Crystal Structure of Annexin A8 is Similar to that of Annexin A3
  • The Crystal Structure of Annexin A8 is Similar to that of Annexin A3 (en)
  • Krystalová struktura annexinu A8 je podobná annexinu A3 (cs)
skos:prefLabel
  • The Crystal Structure of Annexin A8 is Similar to that of Annexin A3
  • The Crystal Structure of Annexin A8 is Similar to that of Annexin A3 (en)
  • Krystalová struktura annexinu A8 je podobná annexinu A3 (cs)
skos:notation
  • RIV/61388971:_____/05:00024480!RIV06-AV0-61388971
http://linked.open.../vavai/riv/strany
  • 1131;1139
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • Z(AV0Z50200510)
http://linked.open...iv/cisloPeriodika
  • -
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 516584
http://linked.open...ai/riv/idVysledku
  • RIV/61388971:_____/05:00024480
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • annexin; x-ray crystal structure; intact N terminus (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV
  • [2972018178ED]
http://linked.open...i/riv/nazevZdroje
  • Journal of Molecular Biology
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 345
http://linked.open...iv/tvurceVysledku
  • Hofbauerová, Kateřina
  • Lewit-Bentley, A.
  • Kerboeuf, D.
  • Blondeau, K.
  • Dreyfuss, L.
  • Raguénes-Nicol, C.
  • Renouard, M.
  • Russo-Marie, F.
  • Réty, S.
  • Sopková-de Oliveira Santos, J.
http://linked.open...n/vavai/riv/zamer
issn
  • 0022-2836
number of pages
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