About: Adenodine Receptors Modify NK-Cell-Mediated Cytotoxicity

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Studie byla věnována účinku adenosin A1, A3 a A2A receptorovým agonistům při sledování buňkami zprostředkované cytotoxicity u živočišných species (myš, potkan, prase, lidé). Experimentální modely zahrnovaly stres, transplantované nádory u myší, spontánní malignitu u potkanů a lidí, ontogenezi u prasat. Imunosupresivní účinek A2A receptoru byl nalezen u všech zdravých jedinců, kdežto účinek A1 a A3 adenosin agonistů neovlivnil NK buněčnou aktivitu. A2A agonisté stimulují nezralý a utlumený imunitní systém a rozšiřují potlačenou cytotoxickou funkci u nádory nesoucích jedinců. A1 adenosin agonistický projev byl nalezen u potlačené cytotoxické aktivity u stresovaných myší. (cs) The study was designed to assess the effect of adenosine A (CCPA), A3(NECA) and A2A (CPCA) receptor agonists in natural killer (NK) cell-mediated cytotoxicity across several mammalian species (mouse, rat, pig and human ). The experimental models of restraint stress, transplanted tumors in mice, spontaneous malignancy in rats and humans and ontogeny in pigs were followed. An immunosuppressive effect of A2A receptor-coupling that is comparable in all healthy subjects studied, was noted; while the A1 and A3 adenosine agonist don´t influence significantly the NK cells activity. A2A agonist stimulates the immature and stressed immune systems and amplifies the depressed cytotoxic effector function in tumor-bearing hosts. On the other hand, A1 adenosine receptor agonist suppresses only the cytotoxic activity in stress-conditioned mice. The study was designed to assess the effect of adenosine A (CCPA), A3(NECA) and A2A (CPCA) receptor agonists in natural killer (NK) cell-mediated cytotoxicity across several mammalian species (mouse, rat, pig and human ). The experimental models of restraint stress, transplanted tumors in mice, spontaneous malignancy in rats and humans and ontogeny in pigs were followed. An immunosuppressive effect of A2A receptor-coupling that is comparable in all healthy subjects studied, was noted; while the A1 and A3 adenosine agonist don´t influence significantly the NK cells activity. A2A agonist stimulates the immature and stressed immune systems and amplifies the depressed cytotoxic effector function in tumor-bearing hosts. On the other hand, A1 adenosine receptor agonist suppresses only the cytotoxic activity in stress-conditioned mice. (en)
Title	Adenodine Receptors Modify NK-Cell-Mediated Cytotoxicity Adenodine Receptors Modify NK-Cell-Mediated Cytotoxicity (en) Adenosinové receptory ovlivňují NK buněčnou cytotoxicitu (cs)
skos:prefLabel	Adenodine Receptors Modify NK-Cell-Mediated Cytotoxicity Adenodine Receptors Modify NK-Cell-Mediated Cytotoxicity (en) Adenosinové receptory ovlivňují NK buněčnou cytotoxicitu (cs)
skos:notation	RIV/61388971:_____/04:00107969!RIV/2005/AV0/A53005/N
http://linked.open.../vavai/riv/strany	103
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA304/01/0850), P(GV312/98/K034), P(IAA7020006), Z(AV0Z5020903)
http://linked.open...vai/riv/dodaniDat	2005
http://linked.open...aciTvurceVysledku	Kuldová, Markéta Vannucci, Luca Pospíšil, Miloslav Pompachová, Alexandra Fišerová, Anna
http://linked.open.../riv/druhVysledku	D - Článek ve sborníku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Mikrobiologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	553550
http://linked.open...ai/riv/idVysledku	RIV/61388971:_____/04:00107969
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	ccpa; neca (en)
http://linked.open.../riv/klicoveSlovo	ccpa neca
http://linked.open...ontrolniKodProRIV	[1D912070DE89]
http://linked.open...v/mistoKonaniAkce	Montréal
http://linked.open...i/riv/mistoVydani	Montréal
http://linked.open...i/riv/nazevZdroje	International Congress of Immunology /12./
http://linked.open...in/vavai/riv/obor	EE
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	Ontogenetic development of immune systém cdells and their surface structures The immune recognition of cytotoxic lymphocytes: strategies for cancer immunotherapy The physiological ligand(s) of C-type lectin lectin receptor CD69 expressed on human NK and T cells during malignancy and some infection processes
http://linked.open...UplatneniVysledku	2004
http://linked.open...iv/tvurceVysledku	Vannucci, Luca Kovářů, F. Kovářů, H. Fišerová, Anna Kuldová, Markéta Pospíšil, Miloslav Pucová, Alexandra
http://linked.open...vavai/riv/typAkce	WRD - Světová
http://linked.open.../riv/zahajeniAkce	2004-07-18 (xsd:date)
http://linked.open...n/vavai/riv/zamer	Výzkum buněčné a molekulární biologie, genetiky, fyziologie a ekologie mikroorganizmů, mikrobní biotechnologie; studium imunitních procesů
number of pages	1 (xsd:int)
http://purl.org/ne...btex#hasPublisher	Neuveden

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