About: Lincomycin, clindamycin and their applications     Goto   Sponge   NotDistinct   Permalink

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  • Lincomycin a clindamycin jsou lincosamidová antibiotika použitá v klinické praxi. Obě antibiotika jsou bakteriostatická a inhibují protein syntézu v citlivých bakteriích. Mohou být dokonce je bakteriostatické ve vyšší koncentraci kterých může být dosaženo v živém organismu. Clindamycin je obvykle více aktivní než lincomycin při bakteriálních infekcích, zvláště způsobených anaerobními druhy; a může být tak užívaný pro zacházení s důležitým prvokem nemoci, například malárie, nejvíce účinně v kombinaci s primaquine. Rezistence k lincomycinu a clindamycinu může být způsoben metylací 23S ribosomalní RNA, modifikací antibiotik zvláštním enzymem nebo aktivním vytékáním z periplasmatického prostoru. (cs)
  • Lincomycin and clindamycin are lincosamide antibiotics used in clinical practice. Both antibiotics are bacteriostatic and inhibit protein synthesis in sensitive bacteria. They may even be bactericidal at the higher concentrations that can be reached in vivo . Clindamycin is usually more active than lincomycin in the treatment of bacterial infections, in particular those caused by anaerobic species; and it can also be used for the treatment of important protozoal diseases, e.g. malaria, most effectively in combination with primaquine. Resistance to lincomycin and clindamycin may be caused by methylation of 23S ribosomal RNA, modification of the antibiotics by specific enzymes or active efflux from the periplasmic space.
  • Lincomycin and clindamycin are lincosamide antibiotics used in clinical practice. Both antibiotics are bacteriostatic and inhibit protein synthesis in sensitive bacteria. They may even be bactericidal at the higher concentrations that can be reached in vivo . Clindamycin is usually more active than lincomycin in the treatment of bacterial infections, in particular those caused by anaerobic species; and it can also be used for the treatment of important protozoal diseases, e.g. malaria, most effectively in combination with primaquine. Resistance to lincomycin and clindamycin may be caused by methylation of 23S ribosomal RNA, modification of the antibiotics by specific enzymes or active efflux from the periplasmic space. (en)
Title
  • Lincomycin, clindamycin and their applications
  • Lincomycin, clindamycin and their applications (en)
  • Linkomycin, klindamycin a jejich aplikace (cs)
skos:prefLabel
  • Lincomycin, clindamycin and their applications
  • Lincomycin, clindamycin and their applications (en)
  • Linkomycin, klindamycin a jejich aplikace (cs)
skos:notation
  • RIV/61388971:_____/04:00100373!RIV/2005/AV0/A53005/N
http://linked.open.../vavai/riv/strany
  • 455;464
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(GA204/01/1004), Z(AV0Z5020903)
http://linked.open...iv/cisloPeriodika
  • -
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
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  • 571568
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  • RIV/61388971:_____/04:00100373
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  • streptomyces lincolnensis (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV
  • [A90033409960]
http://linked.open...i/riv/nazevZdroje
  • Applied Microbiology and Biotechnology
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
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http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 64
http://linked.open...iv/tvurceVysledku
  • Řezanka, Tomáš
  • Spížek, Jaroslav
http://linked.open...n/vavai/riv/zamer
issn
  • 0175-7598
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