About: Breast cancer-associated protein - a novel binding partner of Mason-Pfizer monkey virus protease

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About: Breast cancer-associated protein - a novel binding partner of Mason-Pfizer monkey virus protease Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	We identified breast cancer-associated protein (BCA3) as a novel binding partner of Mason-Pfizer monkey virus (MPMV) protease (PR). The interaction was confirmed by co-immunoprecipitation and immunocolocalization of MPMV PR and BCA3. Full-length but not C-terminally truncated BOA3 was incorporated into MPMV virions. We ruled out the potential role of the G-patch domain, a glycine-rich domain located at the C terminus of MPMV PR, in BCA3 interaction and virion incorporation. Expression of BCA3 did not affect MPMV particle release and proteolytic processing; however, it slightly increased MPMV infectivity. We identified breast cancer-associated protein (BCA3) as a novel binding partner of Mason-Pfizer monkey virus (MPMV) protease (PR). The interaction was confirmed by co-immunoprecipitation and immunocolocalization of MPMV PR and BCA3. Full-length but not C-terminally truncated BOA3 was incorporated into MPMV virions. We ruled out the potential role of the G-patch domain, a glycine-rich domain located at the C terminus of MPMV PR, in BCA3 interaction and virion incorporation. Expression of BCA3 did not affect MPMV particle release and proteolytic processing; however, it slightly increased MPMV infectivity. (en)
Title	Breast cancer-associated protein - a novel binding partner of Mason-Pfizer monkey virus protease Breast cancer-associated protein - a novel binding partner of Mason-Pfizer monkey virus protease (en)
skos:prefLabel	Breast cancer-associated protein - a novel binding partner of Mason-Pfizer monkey virus protease Breast cancer-associated protein - a novel binding partner of Mason-Pfizer monkey virus protease (en)
skos:notation	RIV/61388963:_____/14:00437907!RIV15-GA0-61388963
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(GA204/09/1388)
http://linked.open...iv/cisloPeriodika	6
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Böhmová, Karolína Keprová, Alena Pichová, Iva Rumlová, Michaela Křížová, Ivana Hadravová, Romana Doležal, Michal
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav organické chemie a biochemie AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	5791
http://linked.open...ai/riv/idVysledku	RIV/61388963:_____/14:00437907
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	gene; AKIP1; expression (en)
http://linked.open.../riv/klicoveSlovo	expression gene AKIP1
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[99190F92175E]
http://linked.open...i/riv/nazevZdroje	Journal of General Virology
http://linked.open...in/vavai/riv/obor	EE
http://linked.open...ichTvurcuVysledku	7 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...vavai/riv/projekt	Characterization of novel host cell protein interacting with protease of Mason-Pfizer monkey virus
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	95
http://linked.open...iv/tvurceVysledku	Pichová, Iva Ruml, T. Rumlová, Michaela Křížová, Ivana Doležal, Michal Hadravová, Romana Keprová, Alena Strohalmová, Karolína
http://linked.open...ain/vavai/riv/wos	000338176700019
issn	0022-1317
number of pages	7 (xsd:int)
http://bibframe.org/vocab/doi	10.1099/vir.0.064345-0

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