About: Synthesis and antiviral activity of 4,6-disubstituted pyrimido[4,5-b]indole ribonucleosides

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About: Synthesis and antiviral activity of 4,6-disubstituted pyrimido[4,5-b]indole ribonucleosides Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	A series of new pyrimido[4,5-b]indole ribonucleosides bearing phenyl or hetaryl group at position 4 has been prepared by selective Pd-catalyzed cross-coupling reactions of the corresponding protected 4,6-dichloropyrimido[4,5-b]indole ribonucleoside with (het)arylboronic acids or stannanes followed by deprotection. Some of these compounds displayed antiviral activity against Dengue virus. A series of new pyrimido[4,5-b]indole ribonucleosides bearing phenyl or hetaryl group at position 4 has been prepared by selective Pd-catalyzed cross-coupling reactions of the corresponding protected 4,6-dichloropyrimido[4,5-b]indole ribonucleoside with (het)arylboronic acids or stannanes followed by deprotection. Some of these compounds displayed antiviral activity against Dengue virus. (en)
Title	Synthesis and antiviral activity of 4,6-disubstituted pyrimido[4,5-b]indole ribonucleosides Synthesis and antiviral activity of 4,6-disubstituted pyrimido[4,5-b]indole ribonucleosides (en)
skos:prefLabel	Synthesis and antiviral activity of 4,6-disubstituted pyrimido[4,5-b]indole ribonucleosides Synthesis and antiviral activity of 4,6-disubstituted pyrimido[4,5-b]indole ribonucleosides (en)
skos:notation	RIV/61388963:_____/12:00382291!RIV13-AV0-61388963
http://linked.open...avai/predkladatel	Ústav organické chemie a biochemie AV ČR, v. v. i.
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(GAP207/11/0344)
http://linked.open...iv/cisloPeriodika	20
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Pohl, Radek Hocek, Michal Tichý, Michal
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav organické chemie a biochemie AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	172914
http://linked.open...ai/riv/idVysledku	RIV/61388963:_____/12:00382291
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	nucleosides; deazapurines; antivirals (en)
http://linked.open.../riv/klicoveSlovo	antivirals nucleosides deazapurines
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[16606AEC2C1A]
http://linked.open...i/riv/nazevZdroje	Bioorganic & Medicinal Chemistry
http://linked.open...in/vavai/riv/obor	CC
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	Combinatorial and rational approaches for the synthesis and evaluation of novel modified nucleosides with cytostatic and antimicrobial activity
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	20
http://linked.open...iv/tvurceVysledku	Hocek, Michal Pohl, Radek Tichý, Michal Chen, Y. L. Shi, P. Y. Xu, H. Y. Yokokawa, F.
http://linked.open...ain/vavai/riv/wos	000309594200013
issn	0968-0896
number of pages	11 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.bmc.2012.08.021
is http://linked.open...avai/riv/vysledek of	Synthesis and antiviral activity of 4,6-disubstituted pyrimido[4,5-b]indole ribonucleosides

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