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| Description
| - By combining of systematic synthesis of derivatives and analogues of active compounds, combinatorial approaches and rational design, we propose to device and prepare series of novel nucleoside derivatives and screen them for cytostatic and antimicrobial effects and for inhibition of selected enzymes of nucleic acid metabolism. Metabolism and mechanism of action of actice compounds will be studied and selected most active compounds will be tested in vivo on animal models. The goal is to discover and identify novel nucleosides possessing antitumor effect or activity against pathogenic microorganisms. (en)
- Propojením systematické syntézy derivátů a analogů aktivních látek, kombinatoriálních přístupů a racionálního designu budou navrhovány a syntetizovány série nových nukleosidových derivátů a testována jejich cytostatická a antimikrobiální aktivita a inhibice vybraných enzymů metabolismu nukleových kyselin. Bude studován metabolismus a mechanismus účinku aktivních látek a vybrané nejaktivnější deriváty budou testovány in vivo na zvířecích modelech. Cílem bude nalezení a identifikace nových nukleosidů s protinádorovým účinkem nebo s aktivitou proti patogenním mikroorganismům.
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| Title
| - Combinatorial and rational approaches for the synthesis and evaluation of novel modified nucleosides with cytostatic and antimicrobial activity (en)
- Kombinatoriální a racionální přístupy pro syntézu a studium nových modifikovaných nukleosidů s cytostatickou a antimikrobiální aktivitou
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| skos:notation
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| http://linked.open...avai/cep/aktivita
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| http://linked.open...kovaStatniPodpora
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| http://linked.open...ep/celkoveNaklady
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| http://linked.open...datumDodatniDoRIV
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| http://linked.open...i/cep/druhSouteze
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| http://linked.open...ep/duvernostUdaju
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| http://linked.open.../cep/fazeProjektu
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| http://linked.open...ai/cep/hlavniObor
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| http://linked.open...vai/cep/kategorie
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| http://linked.open.../cep/klicovaSlova
| - nucleosides cytostatics enzyme inhibitors (en)
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| http://linked.open...ep/partnetrHlavni
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| http://linked.open...inujicichPrijemcu
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| http://linked.open...cep/pocetPrijemcu
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| http://linked.open...ocetSpoluPrijemcu
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| http://linked.open.../pocetVysledkuRIV
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| http://linked.open...enychVysledkuVRIV
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| http://linked.open...lneniVMinulemRoce
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| http://linked.open.../prideleniPodpory
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| http://linked.open...iciPoslednihoRoku
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| http://linked.open...atUdajeProjZameru
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| http://linked.open.../vavai/cep/soutez
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| http://linked.open...usZobrazovaneFaze
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| http://linked.open...ai/cep/typPojektu
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| http://linked.open...ep/ukonceniReseni
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| http://linked.open.../cep/vedlejsiObor
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| http://linked.open...ep/zahajeniReseni
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| http://linked.open...tniCyklusProjektu
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| is http://linked.open...vavai/riv/projekt
of | - Synthesis of 2,6-disubstituted pyridin-3-yl C-2 '-deoxyribonucleosides through chemoselective transformations of bromo-chloropyridine C-nucleosides
- Synthesis and Cytostatic and Antiviral Activities of 2 '-Deoxy-2 ',2 '-difluororibo- and 2 '-Deoxy-2 '-fluororibonucleosides Derived from 7-(Het)aryl-7-deazaadenines
- Synthesis and biological activity of benzo-fused 7-deazaadenosine analogues. 5-and 6-substituted 4-amino- or 4-alkylpyrimido [4,5-b]indole ribonucleosides
- Synthesis and Significant Cytostatic Activity of 7-Hetaryl-7-deazaadenosines
- 6-Alkyl-, 6-aryl- or 6-hetaryl-7-deazapurine ribonucleosides as inhibitors of human or MTB adenosine kinase and potential antimycobacterial agents
- Synthesis, Cytostatic, Antimicrobial, and Anti-HCV Activity of 6-Substituted 7-(Het)aryl-7-deazapurine Ribonucleosides
- Structural Basis for Inhibition of Mycobacterial and Human Adenosine Kinase by 7-Substituted 7-(Het)aryl-7-deazaadenine Ribonucleosides
- Phosphoramidate pronucleotides of cytostatic 6-aryl-7-deazapurine ribonucleosides
- Sugar-modified derivatives of cytostatic 7-(het)aryl-7-deazaadenosines: 2'-C-methylribonucleosides, 2'-deoxy-2'-fluoroarabinonucleosides, arabinonucleosides and 2'-deoxyribonucleosides
- Synthesis of 2'-deoxy-2'-fluororibo- and 2'-deoxy-2',2'-difluororibonucleosides derived from 6-(het)aryl-7-deazapurines
- Synthesis of Substituted Benzyl Homo-C-Ribonucleosides and -Nucleotides as Carba-Analogues of Phosphoribosylanthranilate
- Synthesis and antiviral activity of 4,6-disubstituted pyrimido[4,5-b]indole ribonucleosides
- Hydroxylation of nitro-(pentafluorosulfanyl)benzenes via vicarious nucleophilic substitution of hydrogen
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| is http://linked.open...vavai/cep/projekt
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