About: Conformationally locked nucleoside analogues based on the bridgehead substituted 7-oxonorbornane and their antiviral properties

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About: Conformationally locked nucleoside analogues based on the bridgehead substituted 7-oxonorbornane and their antiviral properties Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	We report on the preparation of novel 1’-homonucleoside derivatives locked in a West conformation by 1’,4’-bridge consisting of annulated benzene or naphthalene ring. The crucial step of the synthesis was Diels-Alder reaction of an appropriate aryne with a suitable furane derivative. Antiviral properties of novel compounds were studied and slight activity against HCV was detected in several compounds. We report on the preparation of novel 1’-homonucleoside derivatives locked in a West conformation by 1’,4’-bridge consisting of annulated benzene or naphthalene ring. The crucial step of the synthesis was Diels-Alder reaction of an appropriate aryne with a suitable furane derivative. Antiviral properties of novel compounds were studied and slight activity against HCV was detected in several compounds. (en)
Title	Conformationally locked nucleoside analogues based on the bridgehead substituted 7-oxonorbornane and their antiviral properties Conformationally locked nucleoside analogues based on the bridgehead substituted 7-oxonorbornane and their antiviral properties (en)
skos:prefLabel	Conformationally locked nucleoside analogues based on the bridgehead substituted 7-oxonorbornane and their antiviral properties Conformationally locked nucleoside analogues based on the bridgehead substituted 7-oxonorbornane and their antiviral properties (en)
skos:notation	RIV/61388963:_____/11:00369985!RIV13-AV0-61388963
http://linked.open...avai/predkladatel	Ústav organické chemie a biochemie AV ČR, v. v. i.
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1M0508), Z(AV0Z40550506)
http://linked.open...iv/cisloPeriodika	12
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Dračínský, Martin Hřebabecký, Hubert Nencka, Radim Mertlíková-Kaiserová, Helena Dejmek, Milan
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav organické chemie a biochemie AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	191673
http://linked.open...ai/riv/idVysledku	RIV/61388963:_____/11:00369985
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	1'-homonucleosides; Diels-Alder reaction; antiviral agents (en)
http://linked.open.../riv/klicoveSlovo	1'-homonucleosides Diels-Alder reaction antiviral agents
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[295DEC86A742]
http://linked.open...i/riv/nazevZdroje	Collection of Czechoslovak Chemical Communications
http://linked.open...in/vavai/riv/obor	CC
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	New Antivirals and Antineoplastics
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	76
http://linked.open...iv/tvurceVysledku	Dračínský, Martin Dejmek, Milan Hřebabecký, Hubert Leyssen, P. Mertlíková-Kaiserová, Helena Nencka, Radim Neyts, J.
http://linked.open...ain/vavai/riv/wos	000299816100009
http://linked.open...n/vavai/riv/zamer	Regulace biologických procesů: Chemické modulátory vybraných systémů významných pro medicínu a zemědělství
issn	0010-0765
number of pages	18 (xsd:int)
http://bibframe.org/vocab/doi	10.1135/cccc2011152
is http://linked.open...avai/riv/vysledek of	Conformationally locked nucleoside analogues based on the bridgehead substituted 7-oxonorbornane and their antiviral properties

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